Valeridoids G – Q, Eleven seco‐Iridoids from Valeriana jatamansi and Their Bioactivites. Issue 9 (23rd August 2022)

• Record Type: Journal Article
• Authors: Quan, Li‐Qiu; Wang, Yun; Tang, Jian‐Xian; Zhou, Yan; Liao, Cai‐Cen; Liu, Dan; Zhao, Xu‐Dong; Li, Rong‐Tao; Li, Hong‐Mei
• Is Part Of: Chemistry & biodiversity. Volume 19:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-23
• Subjects: Valeriana jatamansi -- antibacterial -- cytotoxicity -- anti-influenza virus -- anti-inflammatory; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202200609
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Eleven new seco ‐iridoids, valeridoids G‐Q (1 –6 and 8 –12 ), along with four known products, 9‐ epi ‐valtral C (7 ), desacylbaldrinal (13 ), 11‐methoxyviburtinal (14 ) and baldrinal (15 ), were obtained from Valeriana jatamansi . Among them, the new compounds were identified by their NMR, HR‐ESI‐MS spectroscopic data and ECD calculation. Moreover, valeridoid N and O were a pair of C3 epimers, whose ether bonds between C‐1 and C‐3 opened, and new ether bonds formed between C‐3 and C‐6. Valeridoid Q belonged to the C‐1 degradation of seco ‐iridoids. As a result, 9‐ epi ‐valtral C displayed significant inhibition on Streptococcus agalactiae, Staphylococcus aureus, Staphylococcus argenteus, Shigella flexneri and Klebsiella pneumoniae, and valeridoid Q exhibited the most significant inhibition against Salmonella enteritidis . 9‐ Epi ‐valtral C and baldrinal selectively inhibited the growth of human glioma stem cells. Valeridoid Q exhibited significant anti‐influenza activity, while valeridoid O inhibited nitric oxide production. Abstract :