Normal cerebral blood vessels under ultrasound in SD rats of different ages. Issue 3 (4th May 2022)

• Record Type: Journal Article
• Authors: Luo, Bo‐Yan; Liu, Jin‐Xiang; Xiong, Liu‐Lin; Fang, Chang‐Le; He, Yu‐Qi
• Is Part Of: Ibrain. Volume 8:Issue 3(2022)
• Page Start: 346
• Page End: 352
• Publication Date: 2022-05-04
• Subjects: cerebrovascular -- newborn rats -- SD rats -- transcranial Doppler ultrasound; Brain; Neurosciences; Periodicals; 612.8
• DOI: 10.1002/ibra.12035
• Languages: English
• ISSNs: 2313-1934

Abstract

Abstract: The objective of this study was to examine whether ultrasound can examine the development of cerebral vascular structure and cerebral blood flow in Sprague–Dawley (SD) rats by ultrasound in a noninvasive manner, which provides a reference for ultrasound research of SD rats. Thirty‐nine SD rats (7–16 days old) were divided into seven groups according to age, and the number of SD rats in each group was, respectively, 7, 17, 1, 3, 2, 8, and 1. Ultrasound was used to detect cerebral blood vessels, cerebrovascular flow velocity, and heart rate in SD rats in the sagittal and coronal positions, and images were obtained in B‐mode ultrasound. The cerebral vascular structure of 39 SD rats (7–16 days) was dynamically observed under B‐ultrasound. We found that the cerebral vascular structure of the rats aged 7–10 days was clear and detectable. Rats aged 11–16 days of cerebral vascular structures became thinner and undetectable. Quantitative analysis of cerebrovascular flow rate and heart rate in rats found that there was no significant difference in cerebrovascular blood flow rate and heart rate between 7 and 8 days. Ultrasound can also be used in rat animal studies, that is, the cerebral blood flow in rats of different ages can be monitored in real‐time by ultrasound in a noninvasive way. Abstract : The purpose of this article mainly was to investigate whether ultrasound could also be used to monitor the brains of rats in real‐time, and to know what age group of rats could be monitored by ultrasound. The correlation of cerebral vascular structure and vascular flow velocity with age was detected by transcranial ultrasound in neonatal Sprague–Dawley (SD) rats in coronal and deviated positions, respectively, which will provide a basis for the study of some brain diseases and examine whether ultrasound can examine the development of cerebral vascular structure and cerebral blood flow in SD rats by ultrasound in a noninvasive manner, which also provides a reference for ultrasound research of SD rats.