Irregular porous titanium enhances implant stability and bone ingrowth in an intra‐articular ovine model. Issue 10 (11th February 2022)

• Record Type: Journal Article
• Authors: Changoor, Adele; Suderman, R. Peter; Alshaygy, Ibrahim; Fuhrmann, Ariel; Akens, Margarete K.; Safir, Oleg; Grynpas, Marc D.; Kuzyk, Paul R. T.
• Is Part Of: Journal of orthopaedic research. Volume 40:Issue 10(2022)
• Page Start: 2294
• Page End: 2307
• Publication Date: 2022-02-11
• Subjects: biomechanics -- bone ingrowth -- osseointegration -- ovine model -- porous coating; Orthopedics -- Periodicals; Musculoskeletal system -- Periodicals; 616.7
• DOI: 10.1002/jor.25272
• Languages: English
• ISSNs: 0736-0266

Abstract

Abstract: Two commercially available porous coatings, Gription and Porocoat, were compared for the first time in a challenging intra‐articular, weight‐bearing, ovine model. Gription has evolved from Porocoat and has higher porosity, coefficient of friction, and microtextured topography, which are expected to enhance bone ingrowth. Cylindrical implants were press‐fit into the weight‐bearing regions of ovine femoral condyles and bone ingrowth and fixation strength evaluated 4, 8, and 16 weeks postoperatively. Biomechanical push‐out tests were performed on lateral femoral condyles (LFCs) to evaluate the strength of the bone‐implant interface. Bone ingrowth was assessed in medial femoral condyles (MFCs) as well as implants retrieved from LFCs following biomechanical testing using backscattered electron microscopy and histology. By 16 weeks, Gription‐coated implants exhibited higher force (2455 ± 1362 vs. 1002 ± 1466 N; p = 0.046) and stress (12.60 ± 6.99 vs. 5.14 ± 7.53 MPa; p = 0.046) at failure, and trended towards higher stiffness (11, 510 ± 7645 vs. 5010 ± 8374 N/mm; p = 0.061) and modulus of elasticity (591 ± 392 vs. 256 ± 431 MPa; p = 0.061). A strong, positive correlation was detected between bone ingrowth in LFC implants and failure force ( r = 0.93, p < 10 −13 ). By 16 weeks, bone ingrowth in Gription‐coated implants in MFCs was 10.50 ± 6.31% compared to 5.88 ± 2.77% in Porocoat ( p = 0.095). Observations of the bone‐implant interface, made following push‐out testing, showed more bony material consistently adhered to Gription compared to Porocoat at all three time points. Gription provided superior fixation strength and bone ingrowth by 16 weeks.