Self‐assembly of unexpected [Mn(2‐(1‐hydrazonoethyl)pyridine)Cl2]n 1D coordination polymer: Synthesis, structural elucidation, and biological studies. (15th July 2022)

• Record Type: Journal Article
• Authors: Khalil, Tarek E.; Soliman, Saied M.; Khalil, Nessma A.; El‐Dissouky, Ali; Foro, Sabine; Ali, M.; Barakat, Assem
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-15
• Subjects: anti‐cancer agent -- hydrazone -- Mn(II) complex -- Schiff bases -- self‐assembly; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6812
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : Self‐assembly of (((1‐(pyridin‐2‐yl)ethylidene)hydrazono)methyl)phenol ligand (L 1 ) and MnCl2 proceeded with the hydrolysis of the ligand affording the new [Mn (L 2 )Cl2 ]n 1D coordination polymer where L 2 is 2‐(1‐hydrazonoethyl)pyridine. The structure of [Mn(L 2 )Cl2 ]n was confirmed using FTIR, CHN, and X‐ray diffraction of single crystal. It crystallized in the triclinic P‐1 crystal system with a = 7.0697(9) Å, b = 8.878(1) Å, c = 9.402(2) Å, α = 113.99(2)°, β = 95.48(1)°, γ = 111.77(1)°, and V = 479.13(15) Å 3 . The Mn(II) is octahedrally coordinated with two nitrogen atoms from L 2 and four chloride ions. The chloride anions act as bridging ligand that connect the Mn(II) centers leading to the formation of the 1D polymer. Based on continuous shape (CShM) measure tool, the coordination configuration is closer to the octahedron rather than a trigonal prism. Using Hirshfeld analysis, the Cl … H (29.2%), H … C (13.6%), and C … C (3.7%) contacts are the most important in the molecular packing of [Mn(L 2 )Cl2 ]n complex. The ligand L 2 has better antibacterial, antifungal, and antioxidant activities than the Mn(II) complex. The [Mn(L 2 )Cl2 ]n complex has higher cytotoxic effect than L 2 against both lung carcinoma A‐549 and lung fibroblast MRC‐5 cell lines. The IC50 and CC50 values of the Mn(II) complex are 26.09 ± 1.76 and 60.40 ± 3.74 μg ml −1, respectively, while 121.23 ± 5.91 and 241.13 ± 13.29 μg ml −1, respectively, for L 2 . Abstract : A new polymeric Mn(II) complex, [Mn(L 2 )Cl2 ]n, was synthesized using self‐assembly of (((1‐(pyridin‐2‐yl)ethylidene)hydrazono)methyl)phenol ligand (L 1 ) and MnCl2 . Surprisingly, L 1 underwent hydrolysis to 2‐(1‐hydrazonoethyl)pyridine (L 2 ), which was found coordinated with the Mn(II). The new polymer proved to possessed anti‐cancer activity.