A new perspective on endocrine disrupting effects of triphenyltin on marine medaka: From brain transcriptome, gut content metabolome and behavior. (November 2022)

• Record Type: Journal Article
• Authors: He, Shuwen; Yu, Daode; Li, Ping; Zhang, Min; Xing, Shaoying; Liu, Bin; Sun, Cuici; Liu, Ling; Li, Zhi-Hua
• Is Part Of: Chemosphere. Volume 307:Part 4(2022)
• Publication Date: 2022-11
• Subjects: Triphenyltin -- Adverse outcome pathway (AOP) -- Transcriptomics -- Marine medaka; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.136190
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Triphenyltin (TPT) is an endocrine contaminant that is often detected in the environment. However, the mechanism of the effects of TPT on biological systems is not fully understood. Here we exposed marine medaka ( Oryzias melastigma ) to TPT for 21 days. Brain transcriptome, intestinal content metabolism group, and behavior analysis were carried out. Through the comprehensive analysis of multiomics for the in-depth understanding of the ways related to health improvement, we determined that the glycine-serine-threonine metabolic axis was most perturbed by TPT. Through behavioral analysis, it was found that there was behavioral hyperactivity in the exposed group; behavioral hyperactivity may be caused by the interference of TPT with the neuroendocrine system. In order to gain a full understanding of the impacts of TPT on human health, transcriptomic screening of differential genes and an impartial attitude based on bioinformatics were used. Gene-disease interaction analysis using the Comparative Toxicogenomics Database (CTD) revealed the possible effects of TPT on human health. Finally, based on these findings, the relevant adverse outcome pathway (AOP), which is the "epigenetic modification of PPARG leading to adipogenesis, " was identified from AOP Wiki. Further research is required to validate the potential AOP of TPT. Graphical abstract: Image 1 Highlights: TPT can cause hyperactivity in marine medaka. Using marine medaka to multi-omics analyze the toxicity mechanism of TPT. Using CTD to analyze the interference of TPT to Human Health. Using the AOP Wiki to speculate on the potential AOP of TPT.