Genome-wide epigenetic landscape of pig lincRNAs and their evolution during porcine domestication. (29th October 2018)

• Record Type: Journal Article
• Authors: Li, Cencen; Zou, Cheng; Cui, Yong; Fu, Yuhua; Fang, Chengchi; Li, Yao; Li, Jingxuan; Wang, Wen; Xiang, Hui; Li, Changchun
• Is Part Of: Epigenomics. Volume 10:Number 12(2018)
• Page Start: 1603
• Page End: 1618
• Publication Date: 2018-10-29
• Subjects: coding gene -- domestication -- evolution -- expression -- lincRNAs -- liver -- methylation -- pig -- selection signal -- wild; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2017-0117
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: We aimed to identify previously unreported long intergenic noncoding RNAs (lincRNAs) in the porcine liver, an important metabolic tissue, and further illustrate the epigenomic landscapes and the evolution of lincRNAs.Materials & methods: We used porcine omics data and comprehensively analyzed and identified lincRNAs and their methylation, expression and evolutionary patterns during pig domestication.Results: LincRNAs exhibit highly methylated promoter and downstream regions, as well as lower expression levels and higher tissue specificity than protein-coding genes. We identified a batch of lincRNAs with selection signals that are associated with pig domestication, which are more highly expressed in the liver than in other tissues (19:10/8/6/3/2/1/1). Interestingly, the lincRNA linc-sscg1779 and its target gene C6, which is crucial in liver metabolism, are differentially expressed during pig domestication.Conclusion: Although they may originate from noisy transcripts, lincRNAs may be subjected to artificial selection. This phenomenon implies the functional importance of lincRNAs in pig domestication.