Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma. (28th June 2018)

• Record Type: Journal Article
• Authors: Teng, Yaoshu; Li, Yuandong; Lin, Zhihong; Gao, Yueqiu; Cao, Xiaolin; Lou, Xiangyu; Lin, Fengchun; Li, Yong
• Is Part Of: Epigenomics. Volume 10:Number 12(2018)
• Page Start: 1541
• Page End: 1553
• Publication Date: 2018-06-28
• Subjects: bioinformatics -- biomarker -- Human papilloma virus -- inverted papilloma -- microarray -- microRNA -- pathogenesis -- pathway -- sinonasal tumors -- target genes; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2018-0071
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP).Materials & methods: The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods.Results: The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence.Conclusion: MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP. Graphical abstract: