Interdisciplinary intervention for the management of nonmedical opioid use among patients with cancer pain. Issue 20 (23rd August 2022)

• Record Type: Journal Article
• Authors: Arthur, Joseph A.; Edwards, Tonya; Lu, Zhanni; Tang, Michael; Amaram‐Davila, Jaya; Reddy, Akhila; Hui, David; Yennurajalingam, Sriram; Anderson, Aimee E.; Jennings, Kristofer; Reddy, Suresh; Bruera, Eduardo
• Is Part Of: Cancer. Volume 128:Issue 20(2022)
• Page Start: 3718
• Page End: 3726
• Publication Date: 2022-08-23
• Subjects: aberrant -- cancer -- nonmedical -- opioid -- pain -- prescription; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.34392
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: Few studies have assessed interventions aimed at managing nonmedical opioid use (NMOU) behavior among patients with cancer. The authors developed the Compassionate High‐Alert Team (CHAT) intervention to manage patients receiving opioids for cancer pain who demonstrate NMOU behavior. The objective of this study was to determine the change in frequency of NMOU behaviors, pain intensity, and opioid requirements among those who received the intervention. Methods: A total of 130 patients receiving opioids for cancer pain that had documented evidence of NMOU and received the CHAT intervention were reviewed. Demographic and clinical information such as NMOU behaviors, pain scores, and morphine equivalent daily dose at baseline, 3, and 6 months post‐intervention was obtained. Results: NMOU behaviors significantly decreased from a median (interquartile range) of 2 (1–3) at baseline to 0 (0–1) at both 3 and 6 months post‐intervention ( p < .001). A total of 45 of 75 (60%) and 31 of 50 (62%) of CHAT recipients achieved complete response to the intervention at 3 and 6 months, respectively. Higher baseline number of NMOU behaviors was independently associated with patient response to the intervention (odds ratio [OR], 1.97; 95% confidence interval [CI], 1.09–4.28, p = .049 at 3 months; OR, 2.5; 95% CI, 1.20–6.47, p = .03 at 6 months). The median pain score decreased from 7 at baseline to 6 at both 3 and 6 months ( p = .01). Morphine equivalent daily dose did not significantly change during that same period (143 mg/day vs. 139 mg/day, p = .13). Conclusions: Most patients who received the CHAT intervention improved in their NMOU behaviors and pain intensity scores 3 and 6 months post‐intervention. These preliminary findings support the efficacy of CHAT in managing patients receiving opioids for cancer pain who demonstrate NMOU behavior. Abstract : A total of 60% of patients with nonmedical opioid use (NMOU) behaviors who received Compassionate High‐Alert Team (CHAT) intervention became completely opioid‐adherent at 3 months, and most of them remained adherent at 6 months. CHAT recipients experienced a significant reduction in the number of NMOU behaviors, from a median of 2 at baseline to 0 at both 3 and 6 months post‐intervention.