Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases. (November 2022)

• Record Type: Journal Article
• Authors: Islam, Fahadul; Islam, Md Mohaimenul; Khan Meem, Atkia Farzana; Nafady, Mohamed H.; Islam, Md Rezaul; Akter, Aklima; Mitra, Saikat; Alhumaydhi, Fahad A.; Emran, Talha Bin; Khusro, Ameer; Simal-Gandara, Jesus; Eftekhari, Aziz; Karimi, Fatemeh; Baghayeri, Mehdi
• Is Part Of: Chemosphere. Volume 307:Part 3(2022)
• Publication Date: 2022-11
• Subjects: Polyphenols -- Oxidative stress -- Neuroprotection -- Neurodegeneration -- Nanoformulations; NDDs neurodegenerative diseases -- PD Parkinson's disease -- AD Alzheimer's disease -- HD Huntington's disease -- and ALS amyotrophic lateral sclerosis -- OS oxidative stress -- ROS PET -- positron emission tomography MRI -- magnetic resonance imaging NMRS -- nuclear magnetic resonance spectroscopy MRS -- magnetic resonance spectroscopy reactive oxygen species -- Nrf2 nuclear factor erythroid 2-related factor 2 -- Aβ amyloid beta -- ERK extracellular signal-regulated kinase -- PI3K phosphoinositide 3-kinase -- MAPK mitogen-activated protein kinase -- PKC protein kinase C -- Akt/PKB Akt/protein kinase B -- BDNF brain-derived neurotrophic factor -- ARE antioxidant-responsive element -- cAMP cyclic adenosine monophosphate -- MS Multiple sclerosis -- LOX lipoxygenase -- COX cyclooxygenase -- PUPAs polyunsaturated fatty acids -- NFTs neurofibrillary tangles -- TrkB tropomyosin-related kinase B -- NTs neurotrophins -- NGF nerve growth factor -- BBB blood-brain barrier -- CNS central nervous system -- ATP adenosine triphosphate -- APP amyloid precursor protein -- QCM-D quartz crystal microbalance with dissipation monitoring -- TNF-α tumor necrosis factor-alpha -- NF-κB nuclear factor kappa B -- iNOS nitric oxide synthase -- HO-1 heme oxygenase 1 -- SDAT sporadic dementia of Alzheimer's -- GSH glutathione -- TEM transmission electron microscope -- IL-1 interleukin 1 -- NMDA N-methyl-d-aspartate -- PTK protein tyrosine kinase -- SLNs solid lipid nanoparticles -- PLGA poly lactic-co-glycolic acid -- SOD superoxide dismutase -- PAR-1 protease-activated receptor 1 -- and RES-HAS-NPs human serum albumin nanoparticles -- LRRK2 leucine-rich repeat kinase -- MAOIs manoamine oxidase inhibitors; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.136020
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Neurodegenerative diseases (NDDs) are conditions that cause neuron structure and/or function to deteriorate over time. Genetic alterations may be responsible for several NDDs. However, a multitude of physiological systems can trigger neurodegeneration. Several NDDs, such as Huntington's, Parkinson's, and Alzheimer's, are assigned to oxidative stress (OS). Low concentrations of reactive oxygen and nitrogen species are crucial for maintaining normal brain activities, as their increasing concentrations can promote neural apoptosis. OS-mediated neurodegeneration has been linked to several factors, including notable dysfunction of mitochondria, excitotoxicity, and Ca 2+ stress. However, synthetic drugs are commonly utilized to treat most NDDs, and these treatments have been known to have side effects during treatment. According to providing empirical evidence, studies have discovered many occurring natural components in plants used to treat NDDs. Polyphenols are often safer and have lesser side effects. As, epigallocatechin-3-gallate, resveratrol, curcumin, quercetin, celastrol, berberine, genistein, and luteolin have p-values less than 0.05, so they are typically considered to be statistically significant. These polyphenols could be a choice of interest as therapeutics for NDDs. This review highlighted to discusses the putative effectiveness of polyphenols against the most prevalent NDDs. Graphical abstract: Image 1 Highlights: Polyphenols may be beneficial for treating neurodegenerative diseases. Oxidative stress plays an important role in the development of neurodegeneration. Neurotrophins are considered as critical targets for polyphenols that have anti-neurodegenerative disease properties. Nanopolyphenols also shows neuroprotective properties.