Detection of m6A-associated SNPs as potential functional variants for coronary artery disease. (October 2018)

• Record Type: Journal Article
• Authors: Mo, Xing-Bo; Lei, Shu-Feng; Zhang, Yong-Hong; Zhang, Huan
• Is Part Of: Epigenomics. Volume 10:Number 10(2018)
• Page Start: 1279
• Page End: 1287
• Publication Date: 2018-10
• Subjects: ADAMTS7 -- coronary artery disease -- eQTL -- FTO -- gene expression -- genome-wide association study -- m6A -- multifunctional variants -- single nucleotide polymorphism -- transcription regulation; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2018-0007
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To investigate the effects of m 6 A-single nucleotide polymorphisms (SNPs) on coronary artery disease (CAD).Methods: We examined the association of m 6 A-SNPs with CAD in about 185, 000 cases and controls and further performed eQTL and differential expression analyses to support the identified m 6 A-SNPs.Results: Among the 4390 m 6 A-SNPs detected, 304 seemed to be associated with CAD (p < 0.05). SNP rs12286 was significantly associated with CAD at genome-wide level (p = 4.5 × 10 −9 ). rs12286 was predicted to influence m 6 A methylation and have the potential to alter regulatory motifs binding, which may in turn regulate the expression of ADAMTS7 (p = 1.26 × 10 −8 ).Conclusion: The present study found plenty of CAD-associated m 6 A-SNPs and demonstrated the potential functionality of the identified SNPs.