Chemical composition, antioxidant and anticholinesterase activity of the essential oil of algerian cachrys sicula L. Issue 16 (29th July 2022)

• Record Type: Journal Article
• Authors: Tahar, Smaili; Hamdi, Bendif; Flamini, Guido; Mehmet, Öztürk; Duru, Mehmet Emin; Bruno, Maurizio; Maggi, Filippo
• Is Part Of: Natural product research. Volume 36:Issue 16(2022)
• Page Start: 4094
• Page End: 4102
• Publication Date: 2022-07-29
• Subjects: Cachrys sicula L. -- essential oil -- GC-MS -- antioxidant -- anticholinesterase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1969567
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In this work, in order to explore a new Algerian medicinal plant used in traditional medicine, the essential oil of the leaves of Cachrys sicula L. (Apiaceae) collected from Algeria, obtained by hydrodistillation, was analyzed by GC/MS. Thirty-two compounds were identified accounting for 98.6% of the total oil, which is characterized by a high content of monoterpene hydrocarbons (74.8%). The main constituents of the essential oil were β-pinene (17.9%), sabinene (17.8%), myrcene (12%), and α-pinene (11.4%). In vitro antioxidant activity of the essential oil was assayed by three methods, namely ABTS +, metal chelating, and DPPH assays. The antioxidant activity of the oil was higher in the ABTS + method. Anticholinesterase activity was screened by the Ellman method against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which are the chief enzymes of Alzheimer's disease. The results showed mild acetylcholinesterase and good butyrylcholinesterase inhibitory effects. Graphical Abstract: UF0001