A new alkaloid from Portulaca oleracea L. and its anti-inflammatory activity. Issue 18 (8th September 2022)

• Record Type: Journal Article
• Authors: Liu, Fangxuan; Cui, Xinyu; Duan, Yang; Guo, Shengnan; Liu, Jinpeng; Ying, Xixiang
• Is Part Of: Natural product research. Volume 36:Issue 18(2022)
• Page Start: 4709
• Page End: 4713
• Publication Date: 2022-09-08
• Subjects: Portulaca oleracea L. -- alkaloid -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.2000984
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new alkaloid, identified as ( E )-2-(4-hydroxyphenyl)-3-(pyridazin-3-yl)-acrylaldehyde, named oleradazine, was isolated from Portulaca oleracea L., and the structure was elucidated using spectroscopic methods, including 1D and 2D NMR spectroscopic and UHPLC-ESI-QTOF/MS methods. In addition, the compound was used to investigate its anti-inflammatory activity in lipopolysaccharide-stimulated macrophages. It was suggested that the oleradazine can significantly inhibit the inflammatory factors, interleukin 1 β and nitric oxide in lipopolysaccharide-stimulated RAW 264.7 cells by enzyme-linked immunosorbent assays. Graphical Abstract: UF0001