A new flavonoid glycoside from Tapinanthus sp. (Loranthaceae) and evaluation of anticancer activity of extract and some isolated compounds. Issue 16 (29th July 2022)

• Record Type: Journal Article
• Authors: Gade, Isaac Silvère; Chadeneau, Corinne; Richard, Tagne Simo; Atchade, Alex De Théodore; Talla, Emmanuel; Seite, Paul; Vannier, Brigitte; Guillard, Jérôme; Laurent, Sophie; Henoumont, Celine; Nwabo, Armel H. Kamdje; Muller, Jean-Marc
• Is Part Of: Natural product research. Volume 36:Issue 16(2022)
• Page Start: 4085
• Page End: 4093
• Publication Date: 2022-07-29
• Subjects: Tapinanthus sp. -- tapinantoside -- flavonoid glycoside -- anticancer activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1963243
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The present work describes the isolation and anticancer activity of Tapinanthus sp. which is a hemi parasitic plant harvested on Combretum glutinosum, the host plant. Phytochemical study afforded a new flavonoid glycoside, tapinantoside (1 ) isolated for the first time from natural source, alongside six known compounds (2 -7 ). Structure of compounds were elucidated by extensive spectroscopic analyses including 1 D and 2 D NMR, mass spectrometry and by comparison with literature data. The anticancer activity of extract and some isolated compounds were evaluated on glioblastoma (U87MG, C6) and prostate (PC-3) cancer cells. The methanol leaves extract showed good anticancer activity against U87 (IC50 = 21.40 µg/mL) and PC-3 cells (IC50 = 10.26 µg/mL). Compound 3 powerfully inhibits the proliferation of C6 (IC50 = 38.84 µM) and PC-3 cells (IC50 = 21.33 µM), while its effect was moderated on U87MG cells. Compound 1 and 7 were not active on all tested cancer cell lines. Graphical Abstract: UF0001