Dammarane-type triterpenoid saponins from the flower buds of Panax pseudoginseng with cytotoxic activity. Issue 17 (1st September 2022)

• Record Type: Journal Article
• Authors: Hanh, Tran Thi Hong; Cham, Pham Thi; Anh, Do Hoang; Cuong, Nguyen The; Trung, Nguyen Quang; Quang, Tran Hong; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Minh, Chau Van
• Is Part Of: Natural product research. Volume 36:Issue 17(2022)
• Page Start: 4343
• Page End: 4351
• Publication Date: 2022-09-01
• Subjects: Panax pseudoginseng; Araliaceae -- dammarane-type saponin -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1984908
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical investigation of a methanol extract of Panax pseudoginseng flower buds resulted in the isolation of 22 dammarane-type triterpenoid saponins, including three new compounds, pseudoginsenosides A-C (1 -3 ), and 19 known analogs. Their chemical structures were identified by the comprehensive spectroscopic methods, including 1 D and 2 D NMR and mass spectra. In addition, their cytotoxic effects toward three human carcinoma cell lines, including liver (HepG2), breast (MCF7), and lung (A549) were also evaluated. Graphical Abstract: UF0001