Zanzibar yam (Dioscorea sansibarensis Pax) isolates exhibit cyclooxygenase enzyme and lipid peroxidation inhibitory activities. Issue 18 (8th September 2022)

• Record Type: Journal Article
• Authors: Dissanayake, Amila A.; Mmongoyo, Juma A.; Nair, Muraleedharan G.
• Is Part Of: Natural product research. Volume 36:Issue 18(2022)
• Page Start: 4725
• Page End: 4729
• Publication Date: 2022-09-08
• Subjects: phenanthrenes -- phenolics -- steroidal sapogenins -- antioxidant -- anti-inflammatory; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.2004598
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Several phenanthrenes (1–5 ), phenolics (6–8 ) and steroidal sapogenins (9–11 ) were isolated for the first time from the aqueous and methanolic extracts of Dioscorea sansibarensis Pax yam collected from Tanzania. Chemical structures of all the isolates (1–11 ) were determined by using 1D and 2D nuclear magnetic resonance spectral methods. All pure isolates were evaluated for anti-inflammatory activity using in vitro cyclooxygenase enzyme (COX-1 and -2) inhibitory assays. Among the isolates tested, phenanthrenes 3–5 showed the highest COX-1 and -2 enzyme inhibitory activity whereas phenolics (6–8 ) and steroidal sapogenins (9–11 ) exhibited moderate inhibition when compared to non-steroidal anti-inflammatory drugs aspirin, ibuprofen and naproxen. Compounds 6–11 were evaluated for antioxidant activity using lipid peroxidation inhibitory (LPO) assay for the first time and exhibited moderate LPO inhibition. Graphical Abstract: UF0001