In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits. Issue 18 (8th September 2022)

• Record Type: Journal Article
• Authors: da Silva, Giselle Lopes; Campideli, Mariana Bordin; Ferrari, Anna Beatriz Sabino; Mannochio-Russo, Helena; Fraige, Karina; Dametto, Alessandra Cristina; Bolzani, Vanderlan da Silva; Zeraik, Maria Luiza
• Is Part Of: Natural product research. Volume 36:Issue 18(2022)
• Page Start: 4730
• Page End: 4734
• Publication Date: 2022-09-08
• Subjects: Eugenia pyriformis -- uvaia -- antiglycation activity -- antioxidant -- phenolic compounds -- flavonoids; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.2005049
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Eight phenolic compounds were isolated from Eugenia pyriformis leaves fraction by semi-preparative HPLC and characterized by Nuclear Magnetic Resonance (NMR) and mass spectrometry (ESI-MS). Five compounds were isolated and identified for the first time in E. pyriformis species, while this is the first report of the accumulation of isoquercitrin, quercitrin, and the aglycone quercetin in its leaves. E. pyriformis leaves and fruits extracts, as well as the compounds isolated from the leaves most active fraction, were evaluated for their antiglycation and antioxidant activities. The mixture of myricetin-3- O -(2″- O -galloyl)- α - L -rhamnoside and myricetin-3- O -(4″- O -galloyl)- α - L -rhamnoside showed the highest antiglycation activity. These results suggest that this species is a promising source of bioactive compounds. Further studies to investigate the inhibition of the glycation process in vivo are necessary to evaluate its use in the treatment and/or prevention of advanced glycation end-products (AGEs)-associated diseases. Graphical Abstract: UF0001