Determination of carnitine ester profile in the children with type 1 diabetes: a valuable step towards a better management. (3rd September 2022)

• Record Type: Journal Article
• Authors: Rahmani, Parisa; Abolhasani, Ruhollah; Heidari, Ghobad; Mohebbi, Ali; Sayarifard, Fatemeh; Rabbani, Ali; Vafaei, Nahid; Lotfi, Jabar
• Is Part Of: Archives of physiology and biochemistry. Volume 128:Number 5(2022)
• Page Start: 1209
• Page End: 1214
• Publication Date: 2022-09-03
• Subjects: Acyl carnitine -- free carnitine -- metabolism -- type 1 diabetes -- children; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2020.1762662
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Objective: This study is designed to investigate the levels of carnitine and acylcarnitines (ACs) in the children with diabetes type 1 compared to the healthy subjects. Methods: Forty-two type 1 diabetic children and healthy subjects were recruited in the study, respectively. In addition to FBS and Hb A1C, free carnitine and ACs in butyl-ester form in the fasting blood samples were assessed by isotope dilution mass spectrometry for all diabetics and controls using the tandem mass spectrometry system. Results: Diabetic patients had a higher level of C, C4, C6, C14, C18:2, and C18:2OH. Females had elevated C14:2 compared to the males. The C18:2 and C18:2OH levels were elevated as the Hb A1C level increased. The C18:2, C14OH were mostly increased in the prediabetic and diabetic patients, respectively. Conclusion: Increased ACs level indicates the increased acyl-CoA intermediates for the fatty acids and amino acids oxidation.