Systems Genetic Analysis in GeneNetwork.org. Issue 1 (10th April 2017)

• Record Type: Journal Article
• Authors: Parker, Clarissa C.; Dickson, Price E.; Philip, Vivek M.; Thomas, Mary; Chesler, Elissa J.
• Editors: Gerfen, Charles R.; Holmes, Andrew; Sibley, David; Skolnick, Phil; Wray, Susan
• Is Part Of: Current protocols in neuroscience. Issue 79:Issue 1(2017)
• Page Start: 8.39.1
• Page End: 8.39.20
• Publication Date: 2017-04-10
• Subjects: GeneNetwork -- quantitative trait locus mapping -- recombinant inbred strains -- systems genetics; Neurosciences -- Laboratory manuals; Neurosciences; Cytological Techniques; Histological Techniques; Nervous System -- anatomy & histology; Neurosciences; Laboratory Manual; Laboratory manuals; 612.8
• DOI: 10.1002/cpns.23
• Languages: English
• ISSNs: 1934-8576

Abstract

Abstract: Genome‐wide association studies (GWAS) have emerged as a powerful tool to identify alleles and molecular pathways that influence susceptibility to psychiatric disorders and other diseases. Forward genetics using mouse mapping populations allows for a complementary approach that provides rigorous genetic and environmental control. In this unit, we describe techniques and tools that reduce the technical burden traditionally associated with genetic mapping in mice and enhance their translational utility to human psychiatric disorders. We provide guidance on choosing the appropriate mapping population, discuss the importance of phenotype, and offer detailed instructions on using the Web‐based resource GeneNetwork to aid neuroscientists in better understanding the mechanisms through which genes influence behavior. We believe that the continued development of mouse mapping populations, genetic tools, bioinformatics resources, and statistical methodologies should remain a parallel strategy by which to investigate the genetic and environmental underpinnings of psychiatric disorders and other diseases in humans. © 2017 by John Wiley & Sons, Inc.