A new ent-kaurane diterpenoid from the pericarps of Datura metel. Issue 9 (2nd September 2022)

• Record Type: Journal Article
• Authors: Liu, Yan; Wu, Dan-Dan; Zhou, Yong-Qiang; Wu, Jia-Tong; Qi, Zi-Tang; Algradi, Adnan Mohammed; Pan, Juan; Guan, Wei; Yang, Bing-You; Kuang, Hai-Xue
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 9(2022)
• Page Start: 884
• Page End: 890
• Publication Date: 2022-09-02
• Subjects: Solanaceae -- Datura metel -- pericarps -- diterpenoid; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1981874
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new ent-kaurane diterpenoid, named kaurane daturoside A (1 ), was isolated from the 70%-EtOH extract of dried pericarps of Datura metel L., along with six known terpenoids, 16 α, 17-dihydroxy-ent-kauran-19-diglycoside (2 ), cyclosieversioside F (3 ), astragaloside II (4 ), ginsenoside Rg1 (5 ), astrojanoside A (6 ), celerioside E (7 ). The isolated structures were elucidated by means of spectroscopic analyses, and the compounds 2, 3, 7 were separated from Solanaceae for the first time. Meanwhile, among isolates, compounds 2 and 5 exhibited anti-inflammatory activities against LPS-activated RAW264.7 cells (IC50 <11.00 μ M). Graphical Abstract: UF0001