A patent review of pharmaceutical and therapeutic applications of oxadiazole derivatives for the treatment of chronic diseases (2013–2021). (2nd September 2022)

• Record Type: Journal Article
• Authors: Hassan, Abbas; Khan, Abid Hussain; Saleem, Faiza; Ahmad, Haseen; Khan, Khalid Mohammed
• Is Part Of: Expert opinion on therapeutic patents. Volume 32:Number 9(2022)
• Page Start: 969
• Page End: 1001
• Publication Date: 2022-09-02
• Subjects: Oxadiazole -- anticancer -- antibiotic -- antifungal -- receptor modulators -- S1PR -- drug development; Drugs -- Patents -- Periodicals; 615.10272
• DOI: 10.1080/13543776.2022.2116312
• Languages: English
• ISSNs: 1354-3776

Abstract

ABSTRACT: Introduction: Oxadiazole is a unique class of heterocycle, possessing numerous important biomedical and therapeutic applications, such as anti-bacterial, anti-cancer, anti-inflammatory, inhibitors for diverse enzymes, receptor modulators, and neuroprotective properties. The rapid development in the field of oxadiazole-containing structures is confirmed by the development of numerous clinical drugs, such as doxazosin, nesapidil, pleconaril, fasiplon, ataluren, zibotentan, and prenoxdiazine as selected examples. Areas covered: This review provides a comprehensive overview of the range of biological applications of oxadiazole-containing drugs in a range of patents from 2013 to 2021. The information was collected from available data sources including SciFinder, Reaxys, MedLine, and Chemical Abstracts. Expert opinion: Oxadiazole is an established class of compounds with fascinating biological properties. The importance of oxadiazoles can be recognized by their enormous application in a wide spectrum of medicinal chemistry from anticancer, lantibiotics, and antidiabetics to their use in agriculture and neuroprotection. For instance, the oxadiazole-based compounds have shown the ability to modulate a variety of receptors including the M4 receptor agonists, S1P1 receptor modulators, SSTR5 antagonists, orexin type-2 receptor agonists, liver X receptor agonists, and many more. This testifies to the special features associated with the oxadiazole scaffold, making it a significant pharmacophore.