Alkaloids from endophytic fungus Aspergillus fumigatus HQD24 isolated from the Chinese mangrove plant Rhizophora mucronata. Issue 19 (21st September 2022)

• Record Type: Journal Article
• Authors: Zou, Renjian; Wei, Chengwen; Zhang, Xuexia; Zhou, Dongdong; Xu, Jing
• Is Part Of: Natural product research. Volume 36:Issue 19(2022)
• Page Start: 5069
• Page End: 5073
• Publication Date: 2022-09-21
• Subjects: Rhizophora mucronata -- mangrove endophytic fungi -- Aspergillus fumigatus HQD24 -- alkaloids -- biological evaluation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1916017
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Chemical investigation of endophytic fungus Aspergillus fumigatus HQD24, isolated from the flower of Rhizophora mucronata led to the isolation of eight alkaloids, including pyripyropene A (1 ), 1, 11-dideacetyl-pyripyropene A (2 ), pyripyropene E (3 ), chaetominine (4 ), tryptoquivaline J (5 ), fumitremorgin C (6 ), 1-acetyl-β-carboline (7 ), and nicotinic acid (8 ). Their structures were unambiguously elucidated on the basis of extensive spectroscopic data and comparison with the data of literature. Compound 2 was known as a synthetic product and isolated as a natural product for the first time. The immunosuppressive and cytotoxic activities of all isolated compounds were evaluated. Graphical Abstract: UF0001