A reusable MOF supported single-site nickel-catalyzed direct N-alkylation of anilines with alcohols. (8th October 2022)

• Record Type: Journal Article
• Authors: Lu, Yuanyuan; Chai, Huining; Yu, Kun; Huang, Chaonan; Li, Yujie; Wang, Jinyu; Ma, Jiping; Tan, Weiqiang; Zhang, Guangyao
• Is Part Of: Tetrahedron. Volume 124(2022)
• Publication Date: 2022-10-08
• Subjects: N-alkylation -- Borrowing hydrogen strategy -- Earth-abundant metal -- Metal-organic framework; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2022.132993
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: The direct N -alkylation of amines with alcohols is an efficient route through a borrowing hydrogen (BH) strategy. Herein, a highly selective, and reusable Ni(II)-bipyridine-based metal-organic framework (MOF) catalyst was designed for this organic transformation. This earth-abundant metal-based metal-organic framework (MOF) catalyst significantly outperform their homogeneous analogues and the immobilized catalyst was reusable for at least up to 4 cycles without significant decrease in the yield of the target product. Graphical abstract: Image 1 Highlights: A highly efficient and selective earth-abundant metal-based MOF catalyst has been prepared. The catalytic performance of Bpy-UiO-Ni is superior to its homogeneous counterpart in direct N -alkylation of amines. Efficient recyclability and high stability of the developed catalyst.