Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity. Issue 1 (20th January 2022)

• Record Type: Journal Article
• Authors: Hunter, Kylie E; Johnson, Brittany J; Askie, Lisa; Golley, Rebecca K; Baur, Louise A; Marschner, Ian C; Taylor, Rachael W; Wolfenden, Luke; Wood, Charles T; Mihrshahi, Seema; Hayes, Alison J; Rissel, Chris; Robledo, Kristy P; O'Connor, Denise A; Espinoza, David; Staub, Lukas P; Chadwick, Paul; Taki, Sarah; Barba, Angie; Libesman, Sol; Aberoumand, Mason; Smith, Wendy A; Sue-See, Michelle; Hesketh, Kylie D; Thomson, Jessica L; Bryant, Maria; Paul, Ian M; Verbestel, Vera; Stough, Cathleen Odar; Wen, Li Ming; Larsen, Junilla K; O'Reilly, Sharleen L; Wasser, Heather M; Savage, Jennifer S; Ong, Ken K; Salvy, Sarah-Jeanne; Messito, Mary Jo; Gross, Rachel S; Karssen, Levie T; Rasmussen, Finn E; Campbell, Karen; Linares, Ana Maria; Øverby, Nina Cecilie; Palacios, Cristina; Joshipura, Kaumudi J; González Acero, Carolina; Lakshman, Rajalakshmi; Thompson, Amanda L; Maffeis, Claudio; Oken, Emily; Ghaderi, Ata; Campos Rivera, Maribel; Pérez-Expósito, Ana B; Banna, Jinan C; de la Haye, Kayla; Goran, Michael; Røed, Margrethe; Anzman-Frasca, Stephanie; Taylor, Barry J; Seidler, Anna Lene;
• Other Names: author non-byline.; Seidler Anna Lene author non-byline.; Hunter Kylie author non-byline.; Johnson Brittany author non-byline.; Golley Rebecca author non-byline.; Barba Angie author non-byline.; Askie Lisa author non-byline.; Aberoumand Mason author non-byline.; Libesman Sol author non-byline.; Williams Jonathan author non-byline.; Baur Louise author non-byline.; Chadwick Paul author non-byline.; Espinoza David author non-byline.; Hayes Alison author non-byline.; Marschner Ian author non-byline.; Mihrshahi Seema author non-byline.; O'Connor Denise author non-byline.; Rissel Chris author non-byline.; Robledo Kristy author non-byline.; Sanders Lee author non-byline.; Smith Wendy author non-byline.; Staub Lukas author non-byline.; Sue-See Michelle author non-byline.; Taki Sarah author non-byline.; Taylor Rachael author non-byline.; Webster Angela author non-byline.; Wolfenden Luke author non-byline.; Wood Charles author non-byline.; Yin Shonna author non-byline.; Anzman-Frasca Stephanie author non-byline.; Banna Jinan author non-byline.; Bryant Maria author non-byline.; Byrne Rebecca author non-byline.; Campbell Karen author non-byline.; Rivera Maribel Campos author non-byline.; Corpeleijn Eva author non-byline.; Daniels Lynne author non-byline.; Dennis Cindy-Lee author non-byline.; Haye Kayla dela author non-byline.; Fiks Alexander author non-byline.; Ghaderi Ata author non-byline.; Acero Carolina González author non-byline.; Goran Michael author non-byline.; Gross Rachel author non-byline.; Helle Christine author non-byline.; Hesketh Kylie author non-byline.; Jacobvitz Deborah author non-byline.; Joshipura Kaumudi author non-byline.; Karasz Alison author non-byline.; Karssen Levie author non-byline.; Lakshman Rajalakshmi author non-byline.; Larsen Junilla K author non-byline.; Linares Ana Maria author non-byline.; Maffeis Claudio author non-byline.; Messito Mary Jo author non-byline.; Oken Emily author non-byline.; Ong Ken author non-byline.; O'Reilly Sharleen author non-byline.; Øverby Nina author non-byline.; Palacios Cristina author non-byline.; Paul Ian M author non-byline.; Perez-Exposito Ana author non-byline.; Perrin Eliana author non-byline.; Raat Hein author non-byline.; Rasmussen Finn author non-byline.; Røed Margrethe author non-byline.; Rothman Russell author non-byline.; Salvy Sarah-Jeanne author non-byline.; Williams Jennifer Savage author non-byline.; Stough Cathleen Odar author non-byline.; Taylor Barry author non-byline.; Taylor Rachael author non-byline.; Thompson Amanda author non-byline.; Thomson Jessica author non-byline.; Verbestel Vera author non-byline.; Vitolo Márcia Regina author non-byline.; Wasser Heather author non-byline.; Wen Li Ming author non-byline.; Widen Elizabeth author non-byline.; Xia Hongping author non-byline.;
• Is Part Of: BMJ open. Volume 12:Issue 1(2022)
• Publication Date: 2022-01-20
• Subjects: paediatrics -- community child health -- preventive medicine -- public health; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-048166
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. Methods and analysis: Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. Ethics and dissemination: Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. PROSPERO registration number: CRD42020177408.