Prognosis Factors and Outcomes of Neuro-ophthalmologic Sarcoidosis. (19th May 2022)

• Record Type: Journal Article
• Authors: Leclercq, Mathilde; Sené, Thomas; Chapelon-Abric, Catherine; Desbois, Anne Claire; Domont, Fanny; Maillart, Elisabeth; Shor, Natalia; Vignal-Clermont, Catherine; Guéguen, Antoine; Bodaghi, Bahram; Cacoub, Patrice; Touitou, Valerie; Saadoun, David
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 4(2022)
• Page Start: 821
• Page End: 828
• Publication Date: 2022-05-19
• Subjects: Sarcoidosis -- neuro-ophthalmologic -- optic nerve -- orbits MRI -- visual acuity; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1834585
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Background: Neuro-ophthalmologic manifestations are uncommon in sarcoidosis. We aim to assess the prognostic factors and outcome of neuro-ophthalmic sarcoidosis. Methods: We conducted a multicenter retrospective study on patients with neuro-ophthalmic sarcoidosis. Response to therapy was based on visual acuity, visual field, and orbital MRI exam. Factors associated with remission and relapse were analyzed. Results: Thirty-five patients [median (IQR) age of 37 years (26.5–53), 63% of women] were included. The diagnosis of sarcoidosis was concomitant of neuro-ophthalmologic symptoms in 63% of cases. Optic neuritis was the most common manifestation. All patients received corticosteroids and 34% had immunosuppressants. At 6 months, 61% improved, 30% were stable, and 9% worsened. Twenty percent of patients had severe visual deficiency at the end of follow-up. Nonresponders patients had significantly worse visual acuity at baseline ( p = 0.01). Relapses were less frequent in patients with retro-bulbar optic neuropathy ( p = 0.03). Conclusion: Prognosis of neuro-ophthalmic sarcoidosis is poor.