Idiopathic Vitritis after Boston Type 1 Keratoprosthesis Implantation: Incidence, Risk Factors and Outcomes in a Multicentric Cohort. (19th May 2022)

• Record Type: Journal Article
• Authors: Bonnet, Clemence; Chehaibou, Ismael; Ghaffari, Reza; Jackson, Nicholas J.; Bostan, Cristina; Hubschman, Jean-Pierre; Harissi-Dagher, Mona; Aldave, Anthony J.
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 4(2022)
• Page Start: 769
• Page End: 775
• Publication Date: 2022-05-19
• Subjects: Boston type 1 keratoprosthesis -- cornea -- corneal melt -- infectious keratitis -- idiopathic vitritis -- retinal detachment -- risk factor; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1826541
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To determine incidence, risks factors for, and outcomes of idiopathic vitritis (IV) after Boston type 1 keratoprosthesis (KPro) implantation. Methods: Retrospective, consecutive case series. Risk factors were analyzed between IV group and No IV group. Results: IV occurred in 32/350 procedures (9.1%), for an average incidence of 0.02 cases per procedure-year. Presumed infectious keratitis was the only risk factor identified (HR = 7.65) Corneal necrosis and retinal detachment occurred significantly more frequently in IV group (all P < .05). By last follow-up, the cumulative proportion of eyes that maintained a visual acuity >20/200 was significantly lower in IV group ( P = .01), as was the KPro retention rate (HR = 0.26). Conclusions: IV is associated with infectious keratitis, indicating that the vitritis may not be a sterile process. The increased incidence of subsequent complications leads to significantly decreased visual acuity and KPro retention in affected eyes.