Characteristics of our hypoxemic COVID-19 pneumonia patients receiving corticosteroids and mortality-associated factors. Issue 8 (3rd August 2022)

• Record Type: Journal Article
• Authors: Şengül, Aysun; Mutlu, Pınar; Özdemir, Özer; Satıcı, Celal; Turan, Muzaffer Onur; Arslan, Sertaç; Ogan, Nalan; Ekici Ünsal, Zuhal; Bozkuş, Fulsen; Çapraz, Aylin; Demirkol, Mustafa Asım; Mutlu, Levent Cem; Yıldız Gülhan, Pınar; Alkılınç, Ersin; Fazlıoğlu, Nevin; Söyler, Yasemin; Kabalak, Pınar Akın; Kızılgöz, Derya; Turan, Pakize Ayşe; Yıldırım, Fatma; Aydemir, Yusuf; Şen, Nazan; Mirici, Arzu
• Is Part Of: Expert review of respiratory medicine. Volume 16:Issue 8(2022)
• Page Start: 953
• Page End: 958
• Publication Date: 2022-08-03
• Subjects: COVID-19 -- corticosteroid -- hypoxemia -- mortality -- prognosis; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Treatment -- Periodicals; 616.2005
• DOI: 10.1080/17476348.2022.2102480
• Languages: English
• ISSNs: 1747-6348

Abstract

ABSTRACT: Background: COVID-19 is a disease associated with diffuse lung injury that has no proven effective treatment yet. It is thought that glucocorticoids may reduce inflammation-mediated lung injury, disease progression, and mortality. We aimed to evaluate our patient's characteristics and treatment outcomes who received corticosteroids for COVID-19 pneumonia. Methods: We conducted a multicenter retrospective study and reviewed 517 patients admitted due to COVID-19 pneumonia who were hypoxemic and administered steroids regarding demographic, laboratory, and radiological characteristics, treatment response, and mortality-associated factors. Results: Of our 517 patients with COVID-19 pneumonia who were hypoxemic and received corticosteroids, the mortality rate was 24.4% (n = 126). The evaluation of mortality-associated factors revealed that age, comorbidities, a CURB-65 score of ≥ 2, higher SOFA scores, presence of MAS, high doses of steroids, type of steroids, COVID-19 treatment, stay in the intensive care unit, high levels of d-dimer, CRP, ferritin, and troponin, and renal dysfunction were associated with mortality. Conclusion: Due to high starting and average steroid doses are more associated with mortality, high-dose steroid administration should be avoided. We believe that knowing the factors associated with mortality in these cases is essential for close follow-up. The use of CURB-65 and SOFA scores can predict prognosis in COVID-19 pneumonia.