Clinical Characteristics and Outcomes of Short-term Repeat Corneal Transplantation. (19th May 2022)

• Record Type: Journal Article
• Authors: Chen, Xiunian; Li, Ting; Qi, Xiaolin; Shi, Weiyun; Gao, Hua
• Is Part Of: Ocular immunology and inflammation. Volume 30:Number 4(2022)
• Page Start: 855
• Page End: 863
• Publication Date: 2022-05-19
• Subjects: Repeat keratoplasty -- infectious keratitis -- immune keratopathy -- penetrating keratoplasty -- graft survival; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2020.1838557
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose: To explore the primary indications, direct causes and graft survival of short-term repeat keratoplasty. Methods: An analytical cross-sectional study. Results: The primary indications for keratoplasty were infectious keratitis (67.9%) and immune keratopathy (12.8%). The direct causes of graft failure were infectious ulcer (43.6%) and recurrence (30.8%). Pre-operative hypopyon (P = 0.017, HR = 1.757) and use of decellularized porcine corneas as grafts (P = 0.005, HR = 2.690) were independent risk factors for graft failure. The Kaplan–Meier analysis revealed that the 1-year survival rate of 88 repeat grafts was 85.2%, and the 5-year survival rate was 79.2%. The survival rates of the repeat grafts were significantly higher than those of the first grafts (P < 0.001). Conclusion: Infectious keratitis is the most common indication of short-term graft failure and is often failed by infectious ulcer and keratitis recurrence. While the decellularized porcine cornea is a promising application in developing countries, certain difficulties, such as graft melting, remain unresolved.