Influence of blood flow occlusion on muscular recruitment and fatigue during maximal‐effort small muscle‐mass exercise. (13th August 2020)

• Record Type: Journal Article
• Authors: Hammer, Shane M.; Alexander, Andrew M.; Didier, Kaylin D.; Barstow, Thomas J.
• Is Part Of: Journal of physiology. Volume 598:Number 19(2020)
• Page Start: 4293
• Page End: 4306
• Publication Date: 2020-08-13
• Subjects: central and peripheral fatigue -- muscle recruitment -- oxygen delivery; Physiology -- Periodicals; 612.005
• DOI: 10.1113/JP279925
• Languages: English
• ISSNs: 0022-3751

Abstract

Abstract : Key points: The heavy‐to‐severe intensity exercise threshold (i.e. critical force) distinguishes between steady‐state and progressive metabolic and neuromuscular responses to exercise. High levels of skeletal muscle sensory feedback related to peripheral fatigue development are thought to restrict motor unit activation and limit exercise tolerance. Utilizing limb blood flow occlusion, we demonstrate that critical force reflects an oxygen‐delivery‐dependent balance between motor unit activation and peripheral fatigue development. Our findings suggest that mechanisms which determine the total force‐producing capacity of exercising skeletal muscle are significantly altered during blood flow occlusion. These findings may have widespread implications for exercise tolerance in patient populations who experience partial vascular occlusion or altered neuromuscular reflexes. Abstract: High levels of muscle sensory feedback restrict motor unit activation and limit exercise tolerance. The roles of muscle fatigue development and motor unit activation in determining the heavy‐ to severe‐intensity threshold (critical force; CF) remain unclear. This study utilized blood flow occlusion (OCC) to determine relationships between muscle fatigue development and motor unit activation during the determination of CF. We hypothesized that (1) OCC would exacerbate peripheral fatigue development and increase the rate of motor unit deactivation, and (2) blood flow reperfusion (REP) would result in muscle recovery and re‐recruitment of motor units despite continuous maximal effort, (3) resulting in an end‐exercise force not different from CF. Seven young, healthy subjects performed maximal‐effort rhythmic handgrip exercise for 5 min under control conditions (CON) and during OCC and REP. Peripheral fatigue development and motor unit activation were measured via electrical stimulation and electromyography, respectively, during each test. OCC resulted in significantly greater peripheral fatigue development than CON (54.3 ± 34.8%; P < 0.001). Motor unit deactivation was only observed during OCC ( P < 0.001). REP resulted in significant peripheral recovery ( P < 0.001) and the re‐recruitment of motor units ( P < 0.001) to levels not different from CON. While OCC resulted in a significantly greater reduction in force production compared to CON (65.7 ± 35.6%; P < 0.001), REP resulted in the restoration of maximal‐effort force production (266 ± 19 N; P < 0.001) to levels not different from CF (276 ± 55 N). These data suggest that CF reflects an oxygen‐delivery‐dependent balance between motor unit activation and peripheral fatigue development. Furthermore, this study established that mechanisms which determine the total force‐producing capacity of exercising skeletal muscle are altered during OCC. Key points: The heavy‐to‐severe intensity exercise threshold (i.e. critical force) distinguishes between steady‐state and progressive metabolic and neuromuscular responses to exercise. High levels of skeletal muscle sensory feedback related to peripheral fatigue development are thought to restrict motor unit activation and limit exercise tolerance. Utilizing limb blood flow occlusion, we demonstrate that critical force reflects an oxygen‐delivery‐dependent balance between motor unit activation and peripheral fatigue development. Our findings suggest that mechanisms which determine the total force‐producing capacity of exercising skeletal muscle are significantly altered during blood flow occlusion. These findings may have widespread implications for exercise tolerance in patient populations who experience partial vascular occlusion or altered neuromuscular reflexes.