Acid-promoted synthesis of pyrazolo[4, 3-c]quinoline derivatives by employing pyrazole-arylamines and β-keto esters via cleavage of C–C bonds. Issue 18 (17th September 2022)

• Record Type: Journal Article
• Authors: Jiang, Rui; Mu, Yangxiu; Zhang, Wei; Hong, Yu; Iqbal, Zafar; Hou, Jing; Yang, Zhixiang; Tang, Dong
• Is Part Of: Synthetic communications. Volume 52:Issue 18(2022)
• Page Start: 1796
• Page End: 1804
• Publication Date: 2022-09-17
• Subjects: Acid-promoted -- cleavage of C–C bonds -- β-keto esters -- pyrazolo[4, 3-c]quinoline -- pyrazole-arylamines; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2022.2114372
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: An approach for the synthesis of pyrazolo[4, 3-c]quinoline derivatives has been developed by the combination of pyrazole-arylamines and β-keto esters via cleavage of C–C bonds. The strategy shows good tolerance and compatibility with a wide range of functional groups. Moreover, this method features simple conditions, generates a series of alkyl substituted pyrazolo[4, 3-c]quinoline, and provides the desired products in moderate to good yields. Graphical Abstract: UF0001