Microvascular differences in individuals with obesity at risk of developing cardiovascular disease. Issue 9 (2nd August 2021)

• Record Type: Journal Article
• Authors: van der Velden, Anouk I. M.; van den Berg, Bernard M.; de Mutsert, Renée; van der Vlag, Johan; Jukema, J. Wouter; Rosendaal, Frits R.; Rabelink, Ton J.; Vink, Hans
• Is Part Of: Obesity. Volume 29:Issue 9(2021)
• Page Start: 1439
• Page End: 1444
• Publication Date: 2021-08-02
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.23222
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract: Objective: This study aimed to investigate microvascular differences in individuals with obesity at risk for developing cardiovascular disease. Methods: In this cross‐sectional Netherlands Epidemiology of Obesity study, participant sublingual microcirculation was assessed with a newly developed GlycoCheck software (Microvascular Health Solutions Inc., Salt Lake City, Utah), which integrates red blood cell velocity within the smallest capillaries (4‐7 µm) and feed vessels (>10 µm). Framingham Risk Score was used to calculate 10‐year cardiovascular risk, divided into low‐, intermediate‐, and high‐risk groups. ANOVA was used to evaluate microvascular differences among the groups. Results: A total of 813 participants were included. The high‐risk group ( n = 168) was characterized by differences in the microvasculature compared with the low‐risk group ( n = 392): the high‐risk group had a 49% reduction in the number of smallest capillaries and a 9.1‐µm/s (95% CI: 5.2‐12.9) higher red blood cell velocity in the feed vessels. No differences in velocity‐corrected perfused boundary regions were found. Conclusions: It was observed that, with adding red blood cell velocity to the software, sidestream dark field imaging is able to detect microcirculatory differences in a cohort of individuals with obesity at risk for developing cardiovascular disease.