A dual gate-controlled intelligent nanoreactor enables collaborative precise treatment for cancer nanotherapy. Issue 36 (2nd September 2022)

• Record Type: Journal Article
• Authors: Zhang, Huimin; Tang, Weina; Gong, Qi; Yang, Xinyi; Sun, Yunqiang; Dai, Zhichao; Hu, Zunfu; Zheng, Xiuwen
• Is Part Of: Nanoscale. Volume 14:Issue 36(2022)
• Page Start: 13113
• Page End: 13122
• Publication Date: 2022-09-02
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d2nr03676b
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : We have constructed a dual gate-controlled intelligent nanoreactor (HA-DSF@HCuS@FePtMn, HDHF) by the ingenious combination of hollow copper sulfide nanoparticles (HCuS), DSF and FePtMn nanocrystals. Abstract : Recently, disulfiram (DSF), approved by the FDA as an anti-alcoholic drug, has been proved as an effective antitumor drug after chelating with Cu 2+ . To overcome the shortage of intracellular Cu 2+, we have constructed a dual gate-controlled intelligent nanoreactor (HA-DSF@HCuS@FePtMn, HDHF) via the ingenious combination of hollow copper sulfide (HCuS) nanoparticles, DSF and FePtMn nanocrystals. HDHF has a NIR-actuated gate and enzyme-actuated gate that could be opened in the hyaluronidase-abundant tumor microenvironment with NIR laser irradiation to trigger drug (DSF/FePtMn) release and synergistic therapy. Moreover, the FePtMn nanocrystals could continuously release Fe 2+, which could catalyze H2 O2 into highly cytotoxic hydroxyl radicals (˙OH), triggering chemodynamic therapy (CDT). When exposed to NIR laser, HCuS could collapse and release Cu 2+, which could immediately chelate with DSF, forming the effective anticancer drug (Cu(DTC)2 ) and enabling DSF-based chemotherapy. More importantly, the efficient photothermal therapy (PTT) effect of HCuS could accelerate the FePtMn-based CDT and the release of Cu 2+ /DSF, improving tumor treatment efficiency. Thus, this study represents a distinctive paradigm of a dual gate-controlled intelligent nanoreactor enabled PTT-augmented DSF-based chemotherapy and FePtMn-based CDT for cancer nanotherapy.