4-Aminopyrazolopyrimidine scaffold and its deformation in the design of tyrosine and serine/threonine kinase inhibitors in medicinal chemistry. Issue 9 (29th July 2022)

• Record Type: Journal Article
• Authors: Chen, Xiaolu; Huang, Yajiao; Xu, Wanghan; Cai, Yuepiao; Yang, Yuanrong
• Is Part Of: RSC medicinal chemistry. Volume 13:Issue 9(2022)
• Page Start: 1008
• Page End: 1028
• Publication Date: 2022-07-29
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1039/d2md00139j
• Languages: English
• ISSNs: 2632-8682

Abstract

Abstract : Deformation of the 4-aminopyrazolopyrimidine scaffold in designing small-molecule inhibitors. Abstract : The 4-Aminopyrazolopyrimidine scaffold has been an interesting pharmacophore since the disclosure of the intimate connection between small-molecule inhibitors and the treatment of diseases. Modification of the 4-aminopyrazolopyrimidine scaffold according to different targets, especially tyrosine kinase and serine/threonine kinase, has resulted in a variety of small-molecule inhibitors. Kinase inhibitors with 4-aminopyrazolopyrimidine derivatives as scaffolds have been widely applied in the treatment of diseases. In this article, we summarized the reports on 4-aminopyrazolopyrimidine as well as its deformation and the application of its derivatives in designing small-molecule inhibitors and the treatment of diseases.