Aptamer-functionalized fluorine-containing DNAsomes for targeted drug delivery to cancer cells. (31st August 2022)

• Record Type: Journal Article
• Authors: Fan, Shuhua; Liu, Xiaoyan; Yu, Shuxian; Wang, Juan; Li, Chuan; Cheng, Shuang; Hong, Min
• Is Part Of: New journal of chemistry. Volume 46:Number 37(2022)
• Page Start: 17696
• Page End: 17703
• Publication Date: 2022-08-31
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d2nj00967f
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A drug-loaded aptamer functionalized fluorine-containing DNAsome was reported here, which can deliver doxorubicin into cancer cells in a targeted manner through receptor mediated endocytosis and induce the apoptosis of cancer cells. Abstract : Due to the unique hydrophobic and lipophobic physicochemical properties of hydrophobic perfluorocarbons (PFs), here we report a conjugate of a double fluorine-containing lipid and oligonucleotide that can self-assemble into a F-DNAsome to achieve targeted drug delivery to cancer cells. The fluorine-containing DNAsomes (F-DNAsomes) self-assembled from DNA amphiphilic molecules have good biocompatibility, high drug encapsulation ability, enhanced stability and DNA surface modification ability. After integrating the nucleic acid aptamer Sgc8 on the surface of F-DNAsomes through sequence-specific hybridization, this aptamer-functionalized nanosystem can selectively deliver the chemotherapeutic drug doxorubicin (DOX) to targeted cancer cell lines and show higher inhibition efficiency toward cell growth. Studies reveal that the combination of the F-DNAsome structure and the unique physicochemical properties of PFs not only enhances its stability, but also shows potential as nanocarriers for targeted cancer therapy.