Vertical transmission of SARS‐CoV2 during pregnancy: A high‐risk cohort. (14th June 2021)

• Record Type: Journal Article
• Authors: Maeda, Mariane de Fátima Yukie; Brizot, Maria de Lourdes; Gibelli, Maria Augusta Bento Cicaroni; Ibidi, Silvia Maria; Carvalho, Werther Brunow de; Hoshida, Mara Sandra; Machado, Clarisse Martins; Sabino, Ester Cerdeira; Oliveira da Silva, Lea Campos de; Jaenisch, Thomas; Mendes‐Correa, Maria Cássia Jacintho; Mayaud, Philippe; Francisco, Rossana Pulcinelli Vieira
• Is Part Of: Prenatal diagnosis. Volume 41:Number 8(2021)
• Page Start: 998
• Page End: 1008
• Publication Date: 2021-06-14
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.5980
• Languages: English
• ISSNs: 0197-3851

Abstract

Abstract: Objective: Identify the potential for and risk factors of SARS‐CoV‐2 vertical transmission. Methods: Symptomatic pregnant women with COVID‐19 diagnosis in whom PCR for SARS‐CoV‐2 was performed at delivery using maternal serum and at least one of the biological samples: cord blood (CB), amniotic fluid (AF), colostrum and/or oropharyngeal swab (OPS) of the neonate. The association of parameters with maternal, AF and/or CB positivity and the influence of SARS‐CoV‐2 positivity in AF and/or CB on neonatal outcomes were investigated. Results: Overall 73.4% (80/109) were admitted in hospital due to COVID‐19, 22.9% needed intensive care and there were four maternal deaths. Positive RT‐PCR for SARS‐CoV‐2 was observed in 14.7% of maternal blood, 13.9% of AF, 6.7% of CB, 2.1% of colostrum and 3.7% of OPS samples. The interval between COVID‐19 symptoms and delivery was inversely associated with SARS‐CoV‐2 positivity in the maternal blood ( p = 0.002) and in the AF and/or CB ( p = 0.049). Maternal viremia was associated with positivity for SARS‐CoV‐2 in AF and/or CB ( p = 0.001). SARS‐CoV‐2 positivity in the compartments was not associated with neonatal outcomes. Conclusion: Vertical transmission is possible in pregnant women with COVID‐19 and a shorter interval between maternal symptoms and delivery is an influencing factor. Key Points: What is already known about this topic? Few studies systematically evaluated the presence of SARS‐CoV‐2 in biological samples such as amniotic fluid, cord blood, placenta and colostrum Vertical transmission is still uncertain in pregnant women with COVID‐19 What this study add? Vertical transmission is possible in pregnant women with COVID‐19 Maternal viremia is associated with positivity in amniotic fluid and/or cord blood A shorter interval between symptoms and delivery is an influential factor for vertical transmission