1, 3-Dibromo-5, 5-dimethylhydantoin (DBDMH)-promoted cross-coupling of enaminones with phenols under metal-free conditions. (28th September 2022)

• Record Type: Journal Article
• Authors: Duan, Xiaoge; Liu, Kun; Meng, Zhen; Guo, Yufei; Li, Hui; Liu, Ning; Qu, Wanting; Duan, Xiyan; Ma, Junying
• Is Part Of: Tetrahedron letters. Volume 107(2022)
• Publication Date: 2022-09-28
• Subjects: DBDMH-promoted -- Cross-coupling -- Enaminones -- Phenols -- CO bond formation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.154111
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Despite significant progress in the area of enaminone vinyl CH functionalization, approaches for the direct synthesis of phenoxyl enaminone molecules remain a challenge. Here we describe a highly efficient 1, 3‑Dibromo 5, 5-dimethylhydantoin (DBDMH)-promoted cross-coupling reaction between enaminones and phenols. This method provides straightforward access to a wide range of polyfunctionalized aminophenoxyalkenes under mild conditions. The main advantageous features of this method includes a wide substrate scope and good functional group tolerance, operational simplicity, and easily available starting materials.