Biosynthesis of pyrroloindoline-containing natural products. Issue 9 (28th June 2022)

• Record Type: Journal Article
• Authors: Sun, Chenghai; Tian, Wenya; Lin, Zhi; Qu, Xudong
• Is Part Of: Natural product reports. Volume 39:Issue 9(2022)
• Page Start: 1721
• Page End: 1765
• Publication Date: 2022-06-28
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/d2np00030j
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : Recent research on the biosynthesis of pyrroloindoline-containing natural products, including studies investigating their biosynthetic mechanisms and engineering biosynthetic pathways to produce novel products. Abstract : Covering: up to 2022 Pyrroloindoline is a privileged tricyclic indoline motif widely present in many biologically active and medicinally valuable natural products. Thus, understanding the biosynthesis of this molecule is critical for developing convenient synthetic routes, which is highly challenging for its chemical synthesis due to the presence of rich chiral centers in this molecule, especially the fully substituted chiral carbon center at the C3-position of its rigid tricyclic structure. In recent years, progress has been made in elucidating the biosynthetic pathways and enzymatic mechanisms of pyrroloindoline-containing natural products (PiNPs). This article reviews the main advances in the past few decades based on the different substitutions on the C3 position of PiNPs, especially the various key enzymatic mechanisms involved in the biosynthesis of different types of PiNPs.