Recent advances in the synthesis of natural products containing the phloroglucinol motif. Issue 9 (28th June 2022)

• Record Type: Journal Article
• Authors: Phang, Yee Lin; Liu, Song; Zheng, Changwu; Xu, Hongxi
• Is Part Of: Natural product reports. Volume 39:Issue 9(2022)
• Page Start: 1766
• Page End: 1802
• Publication Date: 2022-06-28
• Subjects: Natural products -- Periodicals; Produits naturels -- Périodiques; 547.7
• DOI: 10.1039/d1np00077b
• Languages: English
• ISSNs: 0265-0568

Abstract

Abstract : Phloroglucinol-derived natural products possess notable bioactivities. This review summarizes the recent synthetic approaches to the natural products bearing a phloroglucinol motif, and demonstrates strategies to functionalize the phloroglucinols. Abstract : Covering: June 2009 to 2021 Natural products containing a phloroglucinol motif include simple and oligomeric phloroglucinols, polycyclic polyprenylated acylphloroglucinols, phloroglucinol–terpenes, xanthones, flavonoids, and coumarins. These compounds represent a major class of secondary metabolites which exhibit a wide range of biological activities such as antimicrobial, anti-inflammatory, antioxidant and hypoglycaemic properties. A number of these compounds have been authorized for therapeutic use or are currently being studied in clinical trials. Their structural diversity and utility in both traditional and conventional medicine have made them popular synthetic targets over the years. In this review, we compile and summarise the recent synthetic approaches to the natural products bearing a phloroglucinol motif. Focus has been given on ingenious strategies to functionalize the phloroglucinol moiety at multiple positions. The isolation and bioactivities of the compounds are also provided.