Sleep loss and addiction. (October 2022)

• Record Type: Journal Article
• Authors: López-Muciño, Luis Angel; García-García, Fabio; Cueto-Escobedo, Jonathan; Acosta-Hernández, Mario; Venebra-Muñoz, Arturo; Rodríguez-Alba, Juan Carlos
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 141(2022)
• Publication Date: 2022-10
• Subjects: Drug consumption -- Sleep deprivation -- Insomnia -- Neuronal plasticity -- Delta FosB -- Orexin -- Dopamine; (p)CREB (phosphorylated) cAMP response element-binding protein -- AMPAR AMPA glutamate receptor -- BDNF brain-derived neurotrophic factor -- DA dopamine -- DR dorsal raphe nucleus -- DSM-V Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition -- EEG electroencephalogram -- fMRI functional magnetic resonance imaging -- GABA gamma amino butyric acid -- ICD-10 Tenth Revision of the International Classification of Diseases -- ICSS intracranial self-stimulation -- IEGs immediate early genes -- LC locus coeruleus -- LHA lateral hypothalamic area -- mPFC medial prefrontal cortex -- NAc nucleus accumbens -- NREM non-rapid eye movement -- ORX orexin -- PFC prefrontal cortex -- REM rapid eye movement -- TMN tuberomammillary nucleus -- vACC ventral anterior cingulate cortex -- vmPFC ventromedial prefrontal cortex -- VTA ventral tegmental area; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2022.104832
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: Reducing sleep hours is a risk factor for developing cardiovascular, metabolic, and psychiatric disorders. Furthermore, previous studies have shown that reduction in sleep time is a factor that favors relapse in addicted patients. Additionally, animal models have demonstrated that both sleep restriction and sleep deprivation increase the preference for alcohol, methylphenidate, and the self-administration of cocaine. Therefore, the present review discusses current knowledge about the influence of sleep hours reduction on addictivebehaviors; likewise, we discuss the neuronal basis underlying the sleep reduction-addiction relationship, like the role of the orexin and dopaminergic system and neuronal plasticity (i.e., delta FosB expression). Potentially, chronic sleep restriction could increase brain vulnerability and promote addictive behavior. Graphical Abstract: ga1 Highlights: The reduction of sleep hours in contemporary society can be a factor that facilitates the consumption of addictive substances. Orexins' overstimulation of VTA neurons due to prolonged wakefulness leads to sensitization of the reward circuit. Sleep loss potentially detonates neuronal plasticity that facilitate the development of addictive behavior.