Identifying the white matter structural network of motor reserve in early Parkinson's disease. (September 2022)

• Record Type: Journal Article
• Authors: Kim, Yae Ji; Park, Chan Wook; Shin, Hye Won; Lee, Hye Sun; Kim, Yun Joong; Yun, Mijin; Lee, Phil Hyu; Sohn, Young H.; Jeong, Yong; Chung, Seok Jong
• Is Part Of: Parkinsonism & related disorders. Volume 102(2022)
• Page Start: 108
• Page End: 114
• Publication Date: 2022-09
• Subjects: Motor reserve -- Parkinson's disease -- Structural connectivity -- White matter; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2022.08.005
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Introduction: Motor reserve refers to the individual capacity to cope with nigrostriatal dopamine depletion in Parkinson's disease (PD). This study aimed to explore the white matter structural network associated with motor reserve in patients with newly diagnosed PD. Methods: A total of 238 patients with early-stage drug-naïve PD who underwent 18 F-FP-CIT PET and brain MRI scans at initial assessment were enrolled. We estimated individual motor reserve based on the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) scores and dopamine transporter availability in the posterior putamen using a residual model. Then, we performed threshold-free network-based statistics (TFNBS) analysis to identify the structural brain network associated with the estimated motor reserve. We also assessed the effect of the network connectivity strength on the longitudinal increase in levodopa-equivalent dose (LED). Results: The mean age at PD symptom onset was 69.10 ± 9.03 years and the mean UPDRS-III score at the time of PD diagnosis was 22.44 ± 9.72. TFNBS analysis identified a motor reserve-associated structural network whose nodes were mainly in the frontal region and cerebellum. Higher network strength (i.e., greater motor reserve) was associated with a slower longitudinal increase in LED during a 3-year follow-up period. Conclusion: The structural brain network is associated with motor reserve in patients with PD. Connectivity strength within the identified network indicates the individual's capacity to tolerate PD-related pathologies, which is maintained with disease progression and affects the long-term motor prognosis of PD. Highlights: Motor reserve reflects an individual's capacity to tolerate PD-related pathologies. We identified the structural brain network associated with motor reserve in PD. Nodes of the identified network were mainly in the frontal region and cerebellum. Higher network strength was associated with a slower longitudinal increase in LED.