Effects of erinacine A-enriched Hericium erinaceus on elderly hearing-impaired patients: A double-blind, randomized, placebo-controlled clinical trial. (October 2022)

• Record Type: Journal Article
• Authors: Chan, Yin-Ching; Lin, Tzu-Chun; Chen, Chin-Chu; Lee, Li-Ya; Chen, Wan-Ping; Liu, Ya-Zue; Hwang, Juen-Haur
• Is Part Of: Journal of functional foods. Volume 97(2022)
• Publication Date: 2022-10
• Subjects: Age-related hearing impairment -- Hericium erinaceus -- Pure tone audiometry -- Speech audiometry -- Brain-derived neurotrophic factor -- Nerve growth factor; BDNF brain-derived neurotrophic factor -- NGF nerve growth factor -- PTA-all average pure tone hearing thresholds of all tested frequencies -- PTA-low average pure tone hearing thresholds of 0.25, 0.5, 1 kHz -- PTA-high average pure tone hearing thresholds of 2, 4, 8 kHz -- SRT speech recognition threshold -- SDS speech discrimination scores; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2022.105220
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Hericium erinaceus more effective for patients aged ≧ 65 than those aged < 65. Neurotrophic growth factor levels elevated by consumption of Hericium erinaceus. Pure tone audiometry was improved with Hericium erinaceus. Speech recognition was ameliorated by Hericium erinaceus. Abstract: We aimed to investigate the effects and mechanisms of Hericium erinaceus (HE) on hearing degeneration. By a double-blind, randomized, clinical trial, all 80 hearing-impaired patients aged 50–79 were randomly divided into the two groups, which received HE mycelia (2000 mg/day) and placebo boluses for eight months, respectively. A student's t -test was used to evaluate the differences of the average pure tone hearing threshold of all, low, and high frequencies (PTA-all, PTA-low, and PTA-high); speech recognition threshold (SRT); speech discrimination score (SDS); and serum concentrations of brain-derived neurotrophic factor (BDNF) and neurotrophic growth factor (NGF) between the two study groups. Subgroup analysis by age showed that PTA-high-Right, PTA-all-Left, PTA-high-Left, SRT-Right, SRT-Left, and NGF were significantly different between the two groups among patients aged ≧ 65. HE mycelia treatment could ameliorate hearing loss, especially for high frequencies and speech recognition, and increase NGF in patients aged ≧ 65.