Association between vitamin D status and allergen sensitization in pediatric subjects in the Balearic Islands. Issue 6 (18th April 2021)

• Record Type: Journal Article
• Authors: Segovia‐Ortí, Raquel; Barceló Bennasar, Antonia; De Sotto‐Esteban, Diego; Sanchís Cortés, Pilar; Pons, Jaime
• Editors: Genuneit, Jon
• Is Part Of: Pediatric allergy and immunology. Volume 32:Issue 6(2021)
• Page Start: 1183
• Page End: 1189
• Publication Date: 2021-04-18
• Subjects: hypovitaminosis D -- pediatrics -- pneumo‐allergens -- sensitization -- specific IgE -- vitamin D; Allergy in children -- Periodicals; Immunologic diseases in children -- Periodicals; 617
• DOI: 10.1111/pai.13513
• Languages: English
• ISSNs: 0905-6157

Abstract

Abstract: Introduction: Vitamin D has known effects on the immune system, and its deficiency has been associated with allergen sensitization. Material and methods: A retrospective study was performed to evaluate the association between 25(OH)vitamin D (25(OH)D) and specific IgE for the most frequent allergens in our area in children and adolescents. All subjects under 15 years of age with a determination of Phadiatop ® or Phadiatop Infant ® and close serum 25(OH)D determination were included, from 2012 to 2019. From this sample, demographic and analytical variables were collected: specific IgE to Dermatophagoides pteronyssinus ; dog and cat dander; grass, olive, and pellitory pollens; egg white; and cow milk; as well as complete blood count analysis and immunoglobulins. Results: A total of 749 subjects were recruited. Clusters according to deficiency, insufficiency, or sufficiency of 25(OH)D showed an association with age, Phadiatop ®, D . pteronyssinus, cat and dog dander specific IgE, and a higher frequency of positive allergen sensitization ( P < .05). Logistic regression, compared with vitamin D levels of greater than 30 ng/mL after age adjustment, showed that deficient 25(OH)D was associated with D . pteronyssinus (OR 1.90; 95% CI, 1.25‐2.90) and dog dander (OR, 2.10; 1.10‐4.02); whereas insufficient 25(OH)D was associated with cat dander (OR, 2.46; 1.15‐5.28) and also with D . pteronyssinus (OR, 1.55; 1.06‐2.29) ( P < .05). No associations were found between 25(OH) D levels and other analytical parameters. Conclusion: Vitamin D status is associated with sensitization to D . pteronyssinus, and cat and dog dander in children and adolescents, and also with a higher number of positive specific IgE. Abstract :