White blood count, D‐dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID‐19 patients: The French multicenter CLOTVID retrospective study. (24th May 2021)

• Record Type: Journal Article
• Authors: Galland, Joris; Thoreau, Benjamin; Delrue, Maxime; Neuwirth, Marie; Stepanian, Alain; Chauvin, Anthony; Dellal, Azeddine; Nallet, Olivier; Roriz, Melanie; Devaux, Mathilde; London, Jonathan; Martin‐Lecamp, Gonzague; Froissart, Antoine; Arab, Nouara; Ferron, Bertrand; Groff, Marie‐Helene; Queyrel, Viviane; Lorut, Christine; Regard, Lucile; Berthoux, Emilie; Bayer, Guillaume; Comarmond, Chloe; Lioger, Bertrand; Mekinian, Arsène; Szwebel, Tali‐Anne; Sené, Thomas; Amador‐Boreiro, Blanca; Mangin, Olivier; Sellier, Pierre‐Olivier; Mouly, Stephane; Kevorkian, Jean‐Philippe; Siguret, Virginie; Vodovar, Dominique; Sene, Damien;
• Other Names: Mathieu Albertini investigator.; Sara Bouajila investigator.; Kimbimbi Britany investigator.; Ruxandra Burlacu investigator.; Léa Cacoub investigator.; Karine Champion investigator.; Véronique Delcey investigator.; Jean‐Guillaume Dillinger investigator.; Florine Feron investigator.; Aline Frazier investigator.; Funck‐Bretano Thomas investigator.; Diane‐Cecile Gauthier investigator.; Jean‐François Gautier investigator.; Patrick Henry investigator.; Tessa Huscenot investigator.; Izabel Sarah investigator.; Jaulerry Mathilde investigator.; Moenes Jouabli investigator.; Jean‐Baptiste Julla investigator.; Marie Laloi Michelin investigator.; Pierre Leroy investigator.; Amanda Lopes investigator.; Bruno Megarbane investigator.; Maxime Michon investigator.; Anne‐Lise Munier investigator.; Yoram Nahmani investigator.; Martin Nicol investigator.; Eroan Nicolas investigator.; Audrey Poulat investigator.; Eric Revue investigator.; Pascal Richette investigator.; Jean‐Pierre Riveline investigator.; Emma Rubenstein investigator.; Adrien Zanin investigator.; Clément Aveneau investigator.; Paul Bastard investigator.; Diane Beauvais investigator.; Loredana Boghez investigator.; Alix Borderiou investigator.; Paul Conway investigator.; Lavignia Cosma investigator.; Vincent Davy investigator.; Clément Desjardin investigator.; Sandra Devatine investigator.; Christel Ducroz Gerardin investigator.; Charlotte Dupe investigator.; Chloé Gobert investigator.; Clotilde Gros investigator.; Soumaya Kadiri investigator.; Enmat Khan investigator.; Sandrine Ongnessek investigator.; Fatima Rhmari investigator.; Isabelle Sacco investigator.; Natalia Saptefrat investigator.; Pauline Schaupp investigator.; Justine Serre investigator.; Georgios Sideris investigator.; Sonia Smati investigator.; Marine Tournier investigator.; Pauline Treca investigator.; Tony Truong investigator.; Mathilde Tuffier investigator.; Mattéo Arcelli investigator.; Yvonnick Boue investigator.; Alban Copie investigator.; Nicolas Deye investigator.; Jean‐Michel Ekherian investigator.; Zaccaria Errabih investigator.; Antoine Gonde investigator.; Caroline Grant investigator.; Emmanuelle Guerin investigator.; Adèle Magalhaes investigator.; Isabelle Malissin investigator.; Edouard Meurisse investigator.; Aymen Mrad investigator.; Giulia Naim investigator.; Philippe Nguyen investigator.; Kiyoko Nitenberg investigator.; Adrien Pepin‐Lehalleur investigator.; Arthur Perault investigator.; Lucile Perrin investigator.; Maxime Renaud investigator.; Laetitia Sutterlin investigator.; Maxime Delrue investigator.; Virginie Siguret investigator.; Alain Stepanian investigator.;
• Is Part Of: European journal of haematology. Volume 107:Number 2(2021)
• Page Start: 190
• Page End: 201
• Publication Date: 2021-05-24
• Subjects: COVID‐19 -- D‐dimer -- ferritin -- predictive factor -- pulmonary embolism -- SARS‐CoV‐2 -- white blood count; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.13638
• Languages: English
• ISSNs: 0902-4441

Abstract

Abstract: Background: A high prevalence of pulmonary embolism (PE) has been described during COVID‐19. Our aim was to identify predictive factors of PE in non‐ICU hospitalized COVID‐19 patients. Methods: Data and outcomes were collected upon admission during a French multicenter retrospective study, including patients hospitalized for COVID‐19, with a CT pulmonary angiography (CTPA) performed in the emergency department for suspected PE. Predictive factors significantly associated with PE were identified through a multivariate regression model. Results: A total of 88 patients (median [IQR] age of 68 years [60‐78]) were analyzed. Based on CTPA, 47 (53.4%) patients were diagnosed with PE, and 41 were not. D‐dimer ≥3000 ng/mL (OR 8.2 [95% CI] 1.3‐74.2, sensitivity (Se) 0.84, specificity (Sp) 0.78, P = .03), white blood count (WBC) ≥12.0 G/L (29.5 [2.3‐1221.2], Se 0.47, Sp 0.92, P = .02), and ferritin ≥480 µg/L (17.0 [1.7‐553.3], Se 0.96, Sp 0.44, P = .03) were independently associated with the PE diagnosis. The presence of the double criterion D‐dimer ≥3000 ng/mL and WBC ≥12.0 G/L was greatly associated with PE (OR 21.4 [4.0‐397.9], P = .004). Conclusion: The white blood count, the D‐dimer and ferritin levels could be used as an indication for CTPA to confirm PE on admission in non‐ICU COVID‐19 patients.