Community health status and outcomes after allogeneic hematopoietic cell transplantation in the United States. Issue 4 (21st October 2020)

• Record Type: Journal Article
• Authors: Hong, Sanghee; Brazauskas, Ruta; Hebert, Kyle M.; Ganguly, Siddhartha; Abdel‐Azim, Hisham; Diaz, Miguel Angel; Beattie, Sara; Ciurea, Stefan O.; Szwajcer, David; Badawy, Sherif M.; Gratwohl, Alois A.; LeMaistre, Charles; Aljurf, Mahmoud D. S. M.; Olsson, Richard F.; Bhatt, Neel S.; Farhadfar, Nosha; Yared, Jean A.; Yoshimi, Ayami; Seo, Sachiko; Gergis, Usama; Beitinjaneh, Amer M.; Sharma, Akshay; Lazarus, Hillard; Law, Jason; Ulrickson, Matthew; Hashem, Hasan; Schoemans, Hélène; Cerny, Jan; Rizzieri, David; Savani, Bipin N.; Kamble, Rammurti T.; Shaw, Bronwen E.; Khera, Nandita; Wood, William A.; Hashmi, Shahrukh; Hahn, Theresa; Lee, Stephanie J.; Rizzo, J. Douglas; Majhail, Navneet S.; Saber, Wael;
• Is Part Of: Cancer. Volume 127:Issue 4(2021)
• Page Start: 609
• Page End: 618
• Publication Date: 2020-10-21
• Subjects: allogeneic transplant -- community health -- hematopoietic cell transplantation -- survival; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.33232
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: The association of community factors and outcomes after hematopoietic cell transplantation (HCT) has not been comprehensively described. Using the County Health Rankings and Roadmaps (CHRR) and the Center for International Blood and Marrow Transplant Research (CIBMTR), this study evaluated the impact of community health status on allogeneic HCT outcomes. Methods: This study included 18, 544 adult allogeneic HCT recipients reported to the CIBMTR by 170 US centers in 2014‐2016. Sociodemographic, environmental, and community indicators were derived from the CHRR, an aggregate community risk score was created, and scores were assigned to each patient (patient community risk score [PCS]) and transplant center (center community risk score [CCS]). Higher scores indicated less healthy communities. The impact of PCS and CCS on patient outcomes after allogeneic HCT was studied. Results: The median age was 55 years (range, 18‐83 years). The median PCS was –0.21 (range, –1.37 to 2.10; standard deviation [SD], 0.42), and the median CCS was –0.13 (range, –1.04 to 0.96; SD, 0.40). In multivariable analyses, a higher PCS was associated with inferior survival (hazard ratio [HR] per 1 SD increase, 1.04; 99% CI, 1.00‐1.08; P = .0089). Among hematologic malignancies, a tendency toward inferior survival was observed with a higher PCS (HR, 1.04; 99% CI, 1.00‐1.08; P = .0102); a higher PCS was associated with higher nonrelapse mortality (NRM; HR, 1.08; 99% CI, 1.02‐1.15; P = .0004). CCS was not significantly associated with survival, relapse, or NRM. Conclusions: Patients residing in counties with a worse community health status have inferior survival as a result of an increased risk of NRM after allogeneic HCT. There was no association between the community health status of the transplant center location and allogeneic HCT outcomes. Abstract : A new community risk score for hematopoietic cell transplant recipients, derived from a large publicly available database (the County Health Rankings and Roadmaps), has been developed to describe the community health status of patients and transplant centers. A patient community risk score is associated with nonrelapse mortality and overall survival; however, a center community risk score is not associated with transplant outcomes.