Associations between inhaled doses of PM2.5-bound polycyclic aromatic hydrocarbons and fractional exhaled nitric oxide. (March 2019)

• Record Type: Journal Article
• Authors: Li, Tian; Wang, Yao; Hou, Jian; Zheng, Dan; Wang, Guiyang; Hu, Chen; Xu, Tian; Cheng, Juan; Yin, Wenjun; Mao, Xiang; Wang, Lin; He, Zhenyu; Yuan, Jing
• Is Part Of: Chemosphere. Volume 218(2019)
• Page Start: 992
• Page End: 1001
• Publication Date: 2019-03
• Subjects: Exhaled nitric oxide -- Personal level -- PM2.5-bound PAHs -- Time-activity patterns -- Urinary mono-polycyclic aromatic hydrocarbons; 1-OHNap 1-hydroxynaphthalene -- 1-OHPhe 1-hydroxyphenanthrene -- 1-OHPyr 1-hydroxypyrene -- 2-OHFlu 2-hydroxyfluoren -- 2-OHNap 2-hydroxynaphthalene -- 2-OHPhe 2-hydroxyphenanthrene -- 3-OHPhe 3-hydroxyphenanthrene -- 4-OHPhe 4-hydroxyphennthrene -- 9-OHFlu 9-hydroxyfluoren -- 9-OHPhe 9-hydroxyphenanthrene -- ∑OH-PAHs the total of monohydroxy polycyclic aromatic hydrocarbons -- Ant anthracene -- BaA benzo[a]anthracene -- BaP benzo[a]pyrene -- BbF benzo[b]fluoroanthene -- BghiP benzo[ghi]perylene -- BkF benzo[k]fluoroanthene -- Chr chrysene -- D inhaled doses of PM2.5-PAHs -- DahA dibenzo[a, h]anthracene -- FeNO fractional exhaled nitric oxide -- Flt fluoranthene -- Flu fluorene -- IcdP indeno[123-cd]pyrene -- Phe phenanthrene -- Pyr pyrene -- PM2.5-bound PAHs fine particulate matter (PM2.5)-bound polycyclic aromatic hydrocarbons; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2018.11.196
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Exposure to fine particulate matter (PM2.5 ) is linked to various respiratory outcomes. However, the associations of concentrations of PM2.5 -bound polycyclic aromatic hydrocarbons (PM2.5 -bound PAHs) with airway inflammatory indices remains unclear. To assess effects of short-term exposure to PM2.5 -bound PAHs on fractional exhaled nitric oxide (FeNO), we conducted a pilot study with repeated measures. We recruited 20 postgraduate students in Wuhan city, China, and repeatedly measured outdoor and indoor (including dormitories, offices and laboratories) PM2.5 -bound PAHs concentrations, urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) and FeNO levels in the four seasons. Subsequently, we estimated inhaled doses of PM2.5 -bound PAHs based on the micro-environmental PM2.5 -bound PAHs concentrations, time-activity patterns and referred inhalation rates. We assessed the association of inhaled doses of PM2.5 -bound PAHs with FeNO using linear mixed-effects regression models. We found the positive associations of urinary ∑OH-PAHs levels with inhaled doses of indoor PM2.5 -bound PAHs (including dormitories and offices) (all p < 0.05). A one-unit increase in inhaled doses of PM2.5 -bound PAHs or in urinary concentrations of ∑OH-PAHs was corresponded to a maximum FeNO increase of 13.5% (95% CI: 5.4, 22.2) at lag2 day or of 6.8% (95% CI: 3.4, 10.2) at lag1 day. Inhaled doses of PM2.5 -bound PAHs or urinary OH-PAHs was positively related to increased FeNO, they may be accepted as a short-term biomarker of exposure to PAHs in air. Exposure to PM2.5 -bound PAHs in indoor air may contribute more to the body burden of PAHs than outdoor air, and exhibited stronger effect on increased FeNO rather than urinary OH-PAHs. Graphical abstract: Image 1 Highlights: Inhaled doses of PM2.5 -bound PAHs were higher rather than in outdoor. Inhaled doses of PM2.5 -bound PAHs was positively related to FeNO levels. Inhaled PM2.5 -bound PAHs had a stronger effect on FeNO than urinary OH-PAHs. Increased FeNO was related to lagged and cumulative effects of urinary OH-PAHs.