Molecular Analysis of Genetic Markers for Non‐Hodgkin Lymphomas. (6th April 2017)

• Record Type: Journal Article
• Authors: Sholl, Lynette M.; Longtine, Janina; Kuo, Frank C.
• Editors: Haines, Jonathan L.; Korf, Bruce R.; Morton, Cynthia C.; Seidman, Christine E.; Seidman, J.G.; Smith, Douglas R.
• Is Part Of: Current protocols in human genetics. Volume 93(2017)
• Page Start: 10.14.1
• Page End: 10.14.29
• Publication Date: 2017-04-06
• Subjects: antigen receptor gene rearrangements -- lymphoma -- translocations; Human genetics -- Laboratory manuals; Genetic Techniques; Human genetics; Laboratory manuals; 599.935028
• DOI: 10.1002/cphg.37
• Languages: English
• ISSNs: 1934-8258

Abstract

Abstract: Molecular analysis complements the clinical and histopathologic tools used to diagnose and subclassify hematologic malignancies. The presence of clonal antigen‐receptor gene rearrangements can help to confirm the diagnosis of a B or T cell lymphoma and can serve as a fingerprint of that neoplasm to be used in identifying concurrent disease at disparate sites or recurrence at future time points. Certain lymphoid malignancies harbor a characteristic chromosomal translocation, a finding that may have significant implications for an individual's prognosis or response to therapy. The polymerase chain reaction (PCR) is typically used to detect antigen‐receptor gene rearrangements as well as specific translocations that can be supplemented by fluorescence in situ hybridization (FISH) and karyotype analysis. © 2017 by John Wiley & Sons, Inc.