Efficient Production of Reactive Oxygen Species from Fe3O4/ZnPC Coloaded Nanoreactor for Cancer Therapeutics In Vivo. Issue 3 (13th September 2020)

• Record Type: Journal Article
• Authors: Ong, Wee Kong; Yao, Xuemei; Jana, Deblin; Li, Menghuan; Zhao, Yanli; Luo, Zhong
• Is Part Of: Small structures. Volume 1:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-13
• Subjects: cancer treatment -- Fe3O4 nanoparticles -- Fenton reaction -- photodynamic therapy -- reactive oxygen species; Chemistry -- Periodicals; Science -- Periodicals; Engineering -- Periodicals; 505
• DOI: 10.1002/sstr.202000065
• Languages: English
• ISSNs: 2688-4062

Abstract

Abstract : While Fe3 O4 nanoparticles are frequently exploited for the generation of reactive oxygen species (ROS) in the cancer treatment, its therapeutic performance within a yolk–shell nanostructure for Fenton reaction remains unexplored. To investigate the therapeutic potential, a nanoreactor (YSN@ZnPc@HA) is fabricated by loading zinc phthalocyanine (ZnPc) into a yolk–shell nanocomposite (YSN) consisting of Fe3 O4 nanoparticles encapsulated by MgSiO3, followed by modifying the silica surface with hyaluronic acid (HA). ZnPc is a typical photosensitizer for photodynamic therapy; Fe3 O4 nanoparticles are responsible for Fenton reaction‐based generation of toxic ·OH radicals and also enable magnetic resonance imaging; and HA serves as tumor‐targeting ligand. The obtained YSN@ZnPc@HA is fully characterized by several techniques. Its therapeutic performance is studied both in vitro and in vivo. The experimental results indicate that Fe3 O4 nanoparticles in YSN@ZnPc@HA can successfully enhance the therapeutic efficiency of ZnPc by selectively producing ROS in cancer cells. In addition, YSN@ZnPc@HA shows potent T 2 ‐weighted magnetic resonance imaging capacity. These results collectively demonstrate that the YSN@ZnPc@HA nanoparticles can be used as a robust delivery platform for cancer theranostics. Abstract : A nanoreactor is fabricated by loading zinc phthalocyanine (ZnPc) into a yolk–shell nanocomposite consisting of Fe3 O4 nanoparticle core encapsulated by hyaluronic acid‐modified MgSiO3 shell. The Fe3 O4 core for catalytic Fenton reaction can successfully enhance therapeutic efficiency of ZnPc photosensitizer by selectively producing reactive oxygen species in cancer cells.