Aromatic Compounds in Blood – Determination using Headspace Gas Chromatography with Mass Spectrometric Detection [Biomonitoring Methods, 2018]. Issue 2 (24th April 2018)

• Record Type: Journal Article
• Authors: Göen, T.; Müller, J.; Hoppe, H.‐W.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 3:Issue 2(2018)
• Page Start: 954
• Page End: 974
• Publication Date: 2018-04-24
• Subjects: benzene -- toluene -- chlorobenzene -- ethylbenzene -- o‐xylene -- m‐xylene -- p‐xylene -- styrene -- n‐propylbenzene -- isopropylbenzene -- cumene -- 1, 2, 3‐trimethylbenzene -- hemimellitene -- 1, 2, 4‐trimethylbenzene -- 1, 3, 5‐trimethylbenzene -- mesitylene -- 1, 2, 3, 5‐tetramethylbenzene -- isodurene -- blood -- biomonitoring -- Analyses in Biological Materials -- gas chromatography -- mass spectrometry -- headspace -- GC‐MS; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bi7143e2218
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: The working group „Analyses in Biological Materials" of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The here described analytical method enables the simultaneous determination of benzene, toluene, chlorobenzene, ethylbenzene, o‐xylene, m‐xylene, p‐xylene, styrene, n‐propylbenzene, isopropylbenzene (cumene), 1, 2, 3‐trimethylbenzene (hemimellitene), 1, 2, 4‐trimethylbenzene, 1, 3, 5‐trimethylbenzene (mesitylene) and 1, 2, 3, 5‐tetramethylbenzene (isodurene) in blood. For determination, the blood samples are introduced into headspace vials. The vials are sealed and heated to 50 °C in the autosampler. Subsequently, an aliquot of the vapour phase is injected into the GC system and analysed using mass spectrometry. Calibration standards are prepared in ovine blood and processed in the same way as the samples to be analysed.