Biomarkers in temporomandibular disorder and trigeminal neuralgia: A conceptual framework for understanding chronic pain. Issue 1 (1st January 2020)

• Record Type: Journal Article
• Authors: Doshi, Tina L.; Nixdorf, Donald R.; Campbell, Claudia M.; Raja, Srinivasa N.
• Is Part Of: Canadian journal of pain =. Volume 4:Issue 1(2020)
• Page Start: 1
• Page End: 18
• Publication Date: 2020-01-01
• Subjects: facial pain -- trigeminal neuralgia -- temporomandibular disorder -- biomarkers -- chronic pain -- precision medicine; Pain -- Periodicals; Pain -- Treatment -- Periodicals; Pain; Pain Management; Periodicals; 616.0472
• DOI: 10.1080/24740527.2019.1709163
• Languages: English
• ISSNs: 2474-0527

Abstract

ABSTRACT: In this review, we will explore the use of biomarkers in chronic pain, using the examples of two prototypical facial pain conditions: trigeminal neuralgia and temporomandibular disorder. We will discuss the main categories of biomarkers and identify various genetic/genomic, molecular, neuroradiological, and psychophysical biomarkers in both facial pain conditions, using them to compare and contrast features of neuropathic, nonneuropathic, and mixed pain. By using two distinct model facial pain conditions to explore pain biomarkers, we aim to familiarize readers with different types of biomarkers currently being studied in chronic pain and explore how these biomarkers may be used to develop new precision medicine approaches to pain diagnosis, prognosis, and management.