Molecular characterization and antimicrobial susceptibilities of Clostridium difficile clinical isolates from Victoria, Australia. (August 2015)

• Record Type: Journal Article
• Authors: Mackin, Kate E.; Elliott, Briony; Kotsanas, Despina; Howden, Benjamin P.; Carter, Glen P.; Korman, Tony M.; Riley, Thomas V.; Rood, Julian I.; Jenkin, Grant A.; Lyras, Dena
• Is Part Of: Anaerobe. Volume 34(2015)
• Page Start: 80
• Page End: 83
• Publication Date: 2015-08
• Subjects: Clostridium difficile -- Clostridium difficile epidemiology -- Clostridium difficile toxinotypes -- Clostridium difficile Australia -- Clostridium difficile antibiotic resistance; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2015.05.001
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Some Australian strain types of Clostridium difficile appear unique, highlighting the global diversity of this bacterium. We examined recent and historic local isolates, finding predominantly toxinotype 0 strains, but also toxinotypes V and VIII. All isolates tested were susceptible to vancomycin and metronidazole, while moxifloxacin resistance was only detected in recent strains. Highlights: Clostridium difficile is a nosocomial pathogen, with different strain types causing disease. We have generated a snap-shot of C. difficile strain types circulating in Victoria. The diversity of isolates in Victoria may differ from other parts of the world. Most strains were toxinotype 0, but toxinotypes V and VIII strains were also found. Strains were metronidazole and vancomycin sensitive; 2 were moxifloxacin resistant.