PRR-signaling pathways: Learning from microbial tactics. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Sellge, Gernot; Kufer, Thomas A.
• Is Part Of: Seminars in immunology. Volume 27:Issue 2(2015)
• Page Start: 75
• Page End: 84
• Publication Date: 2015-03
• Subjects: ETI effector-triggered immunity -- IEC intestinal epithelial cells -- LPS lipopolysaccharide -- MAMP microbe-associated-molecular pattern -- MAPK mitogen activated kinase -- NFκB nuclear factor kappa B -- NLR nod-like receptors -- OMV outer-membrane vesicles -- PGN peptidoglycan -- PRR pattern-recognition receptor -- PSA polysaccharide A -- PTI PAMP-triggered immunity -- ROS reactive oxygen species -- TIR toll/interleukin-1 receptor domain -- TLR toll-like receptor -- SCFAs short chain fatty acids; NLR -- TLR -- Signaling -- Kinase -- T3SS -- Actin -- Inflammation; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2015.03.009
• Languages: English
• ISSNs: 1044-5323

Abstract

Highlights: Pathogens use multiple PRR subversion mechanisms to establish infections. The host can sense bacterial-induced modifications of signaling events. Activation and alterations of PRR-signaling by commensals assures homeostasis. Abstract: Recognition of bacterial pathogens by the mammalian host relies on the induction of early innate immune responses initiated by the activation of pattern-recognition receptors (PRRs) upon sensing of their cognate microbe-associated-patterns (MAMPs). Successful pathogens have evolved to intercept PRR activation and signaling at multiple steps. The molecular dissection of the underlying mechanisms revealed many of the basic mechanisms used by the immune system. Here we provide an overview of the different strategies used by bacterial pathogens and commensals to subvert and reprogram PPR-mediated innate immune responses. A particular attention is given to recent discoveries highlighting novel molecular details of the host inflammatory response in mammalian cells and current advances in our understanding of the interaction of commensals with PRR-mediated responses.